Stanene-Based Nanosheets for β-Elemene Delivery and Ultrasound-Mediated Combination Cancer Therapy

被引：160

作者：

Chen, Wei ^{[2
,3
]}

Liu, Chuang ^{[2
,3
]}

Ji, Xiaoyuan ^{[1
,2
,3
]}

Joseph, John ^{[2
,3
]}

Tang, Zhongmin ^{[2
,3
]}

Ouyang, Jiang ^{[2
,3
]}

Xiao, Yufen ^{[2
,3
]}

Kong, Na ^{[2
,3
]}

Joshi, Nitin ^{[2
,3
,4
,5
]}

Farokhzad, Omid C. ^{[2
,3
]}

Tao, Wei ^{[2
,3
]}

Xie, Tian ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Sch Med, Coll Pharm, Hangzhou 311121, Zhejiang, Peoples R China

[2] Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA

[3] Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA

[4] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[5] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 13期

基金：

中国国家自然科学基金;

关键词：

combination cancer therapy; photothermal therapy; sonodynamic therapy; stanene; two-dimensional materials;

D O I：

10.1002/anie.202016330

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ultrasound (US)-mediated sonodynamic therapy (SDT) has emerged as a superior modality for cancer treatment owing to the non-invasiveness and high tissue-penetrating depth. However, developing biocompatible nanomaterialbased sonosensitizers with efficient SDT capability remains challenging. Here, we employed a liquid-phase exfoliation strategy to obtain a new type of two-dimensional (2D) stanenebased nanosheets (SnNSs) with a band gap of 2.3 eV, which is narrower than those of the most extensively studied nanosonosensitizers, allowing a more efficient US-triggered separation of electron (e(-))-hole (h(+)) pairs for reactive oxygen species (ROS) generation. In addition, we discovered that such SnNSs could also serve as robust near-infrared (NIR)-mediated photothermal therapy (PTT) agents owing to their efficient photothermal conversion, and serve as nanocarriers for anticancer drug delivery owing to the inherent 2D layered structure. This study not only presents general nanoplatforms for SDT-enhanced combination cancer therapy, but also highlights the utility of 2D SnNSs to the field of nanomedicine.

引用

页码：7155 / 7164

页数：10

共 61 条

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