Neuropeptide Y modulation of ethanol intake: Effects of ethanol drinking history and genetic background

被引：15
作者：
Badia-Elder, Nancy E. [1 ]
Gilpin, Nicholas W. [1 ]
Stewart, Robert B. [1 ]
机构：
[1] Indiana Univ Purdue Univ, Dept Psychol, Indianapolis, IN 46202 USA
来源：
PEPTIDES | 2007年 / 28卷 / 02期
关键词：
neuropeptide Y; selectively bred alcohol preferring rats; P rats; NP rats; HAD rats; LAD rats; ethanol drinking; stress; anxiety;
D O I：
10.1016/j.peptides.2006.07.028
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Intracerebroventricular administration of NPY suppresses ethanol intake in selectively bred alcohol-preferring rat lines, but not in rats selectively bred for low ethanol drinking or in unselected Wistar rats, when access to ethanol is limited to 2 h/day. However, when rats undergo chronic (24 h/day) ethanol drinking (or exposure to ethanol by vapor inhalation) and have periods of imposed ethanol abstinence, the reductions in ethanol drinking following NPY administration are enhanced in alcohol-preferring rats and are also observed in unselected Wistar rats. Thus, sensitivity to the effects of NPY on ethanol drinking appears to be altered by selective breeding for ethanol preference and by a prior history of chronic but intermittent exposure to ethanol. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：339 / 344
页数：6
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