Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10

被引：8

作者：

Halstrom, Samuel ^{[1
,2
,3
]}

Thomson, Rachel ^{[1
,3
]}

Goullee, Hayley ^{[4
]}

Baltic, Svetlana ^{[5
]}

Allcock, Richard ^{[6
]}

Temple, Suzanna E. L. ^{[4
]}

Price, Patricia ^{[2
,7
]}

机构：

[1] Univ Queensland, Sch Med, Brisbane, Qld, Australia

[2] Curtin Univ, Sch Biomed Sci, Perth, WA, Australia

[3] Greenslopes Private Hosp, Gallipoli Med Res Fdn, Brisbane, Qld, Australia

[4] Harry Perkins Inst Med Res, Perth, WA, Australia

[5] Univ Western Australia, Inst Resp Hlth, Perth, WA, Australia

[6] Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA, Australia

[7] Univ Witwatersrand, Sch Physiol, Johannesburg, South Africa

来源：

HUMAN IMMUNOLOGY | 2017年 / 78卷 / 04期

关键词：

Nontuberculous mycobacteria; Pulmonary disease; IL10; Genetic polymorphism; ASSOCIATION; POLYMORPHISMS;

D O I：

10.1016/j.humimm.2017.02.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic water supplies is common, pulmonary infection and disease are confined to a small proportion of older individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM disease and we demonstrated elevated production of IL-10 by blood leukocytes from patients with pulmonary NTM. Here seven additional polymorphisms in IL10 were investigated in a larger cohort of Caucasian controls and patients with pulmonary NTM disease. This demonstrated a significant association between pulmonary NTM disease and one polymorphism (rs1518111) in strong linkage disequilibrium with rs1800896. (C) 2017 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：391 / 393

页数：3

共 20 条

[1] Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease [J].

Affandi, Jacquita S. ;

Hendry, Shona ;

Waterer, Grant ;

Thomson, Rachel ;

Wallace, Hilary ;

Burrows, Sally ;

Price, Patricia .

HUMAN IMMUNOLOGY, 2013, 74 (10) :1382-1385

[2] A global reference for human genetic variation [J].

Altshuler, David M. ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Donnelly, Peter ;

Eichler, Evan E. ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Green, Eric D. ;

Hurles, Matthew E. ;

Knoppers, Bartha M. ;

Korbel, Jan O. ;

Lander, Eric S. ;

Lee, Charles ;

Lehrach, Hans ;

Mardis, Elaine R. ;

Marth, Gabor T. ;

McVean, Gil A. ;

Nickerson, Deborah A. ;

Wang, Jun ;

Wilson, Richard K. ;

Boerwinkle, Eric ;

Doddapaneni, Harsha ;

Han, Yi ;

Korchina, Viktoriya ;

Kovar, Christie ;

Lee, Sandra ;

Muzny, Donna ;

Reid, Jeffrey G. ;

Zhu, Yiming ;

Chang, Yuqi ;

Feng, Qiang ;

Fang, Xiaodong ;

Guo, Xiaosen ;

Jian, Min ;

Jiang, Hui ;

Jin, Xin ;

Lan, Tianming ;

Li, Guoqing ;

Li, Jingxiang ;

Li, Yingrui ;

Liu, Shengmao ;

Liu, Xiao ;

Lu, Yao ;

Ma, Xuedi ;

Tang, Meifang ;

Wang, Bo .

NATURE, 2015, 526 (7571) :68-+

[3] Nontuberculous Mycobacterial Disease Prevalence and Risk Factors: A Changing Epidemiology [J].

Cassidy, P. Maureen ;

Hedberg, Katrina ;

Saulson, Ashlen ;

McNelly, Erin ;

Winthrop, Kevin L. .

CLINICAL INFECTIOUS DISEASES, 2009, 49 (12) :E124-E129

[4] Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Tuberculosis: A Meta-Analysis [J].

Gao, Xuan ;

Chen, Junjun ;

Tong, Zhongkai ;

Yang, Guangdie ;

Yao, Yinan ;

Xu, Fei ;

Zhou, Jianying .

PLOS ONE, 2015, 10 (06)

[5]

Goullee H., 2016, J NEUROVIROL, P1

[6] An official ATS/IDSA statement: Diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases [J].

Griffith, David E. ;

Aksamit, Timothy ;

Brown-Elliott, Barbara A. ;

Catanzaro, Antonino ;

Daley, Charles ;

Gordin, Fred ;

Holland, Steven M. ;

Horsburgh, Robert ;

Huitt, Gwen ;

Iademarco, Michael F. ;

Iseman, Michael ;

Olivier, Kenneth ;

Ruoss, Stephen ;

von Reyn, C. Fordham ;

Wallace, Richard J., Jr. ;

Winthrop, Kevin .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 175 (04) :367-416

[7]

Hsia TC, 2015, IN VIVO, V29, P695

[8] Interferonγ/1L10 ratio defines the disease severity in pulmonary and extra pulmonary tuberculosis [J].

Jamil, Bushra ;

Shahid, Firdaus ;

Hasan, Zahra ;

Nasir, Nosheen ;

Razzaki, Tashmeem ;

Dawood, Ghaffar ;

Hussain, Rabia .

TUBERCULOSIS, 2007, 87 (04) :279-287

[9] Pulmonary Nontuberculous Mycobacterial Disease Prospective Study of a Distinct Preexisting Syndrome [J].

Kim, Richard D. ;

Greenberg, David E. ;

Ehrmantraut, Mary E. ;

Guide, Shireen V. ;

Ding, Li ;

Shea, Yvonne ;

Brown, Margaret R. ;

Chernick, Milica ;

Steagall, Wendy K. ;

Glasgow, Connie G. ;

Lin, JingPing ;

Jolley, Clara ;

Sorbara, Lynn ;

Raffeld, Mark ;

Hii, Suvimol ;

Avila, Nilo ;

Sachdev, Vandana ;

Barnhart, Lisa A. ;

Anderson, Victoria L. ;

Claypool, Reginald ;

Hilligoss, Dianne M. ;

Garofalo'O, Mary ;

Fitzgerald, Alan ;

Anaya-O'Brien'O, Sandra ;

Darnell, Dirk ;

DeCastrol, Rosamma ;

Menning, Heather M. ;

Ricklefs, Stacy M. ;

Porcella, Stephen F. ;

Olivier, Kenneth N. ;

Moss, Joel ;

Holland, Steven M. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 178 (10) :1066-1074

[10] Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency [J].

Lim, Andrew ;

Allison, Cans ;

Price, Patricia ;

Waterer, Grant .

CLINICAL IMMUNOLOGY, 2010, 137 (02) :296-302

← 1 2 →