Mechanobiology of the intervertebral disc

被引：49

作者：

Lotz, JC ^{[1
]}

Hsieh, AH ^{[1
]}

Walsh, AL ^{[1
]}

Palmer, EI ^{[1
]}

Chin, JR ^{[1
]}

机构：

[1] Univ Calif San Francisco, Orthopaed Bioengn Lab, San Francisco, CA 94143 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2002年 / 30卷

关键词：

apoptosis; biomechanics; remodelling; spine;

D O I：

10.1042/bst0300853

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intervertebral disc degeneration has been linked in humans to extreme spinal loading regimens. However, mechanisms by which spinal force influences disc cellularity, morphology and consequently biomechanical function are unclear. To gain insight into mechanobiological interactions within the disc, we developed an in vivo murine tall-compression model. Results from this model demonstrate how deviations in spinal stress induce a cycle of altered cell function and morphology as the disc remodels to a new homoeostatic configuration.

引用

页码：853 / 858

页数：6

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