Causality of myelodysplasia and acute myeloid leukemia and their genetic abnormalities

被引：41
|
作者：
Pedersen-Bjergaard, J [1 ]
Christiansen, DH [1 ]
Andersen, MK [1 ]
Skovby, F [1 ]
机构：
[1] Univ Copenhagen Hosp, Rigshosp, Juliane Marie Ctr, Dept Clin Genet,Sect Hematol Oncol,Cytogenet Lab, DK-2100 Copenhagen, Denmark
来源：
LEUKEMIA | 2002年 / 16卷 / 11期
关键词：
myelodysplasia; acute myeloid leukemia; therapy related leukemia; epidemiology; chromosome abnormalities; alkylating agents; topoisomerase II inhibitors;
D O I：
10.1038/sj.leu.2402764
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
New insights into causative factors for the development of myelodysplasia (MDS) and acute myeloid leukemia (AML), with associations to specific cytogenetic and genetic abnormalities have been obtained primarily from studies of patients with the therapy-related subsets of the two diseases. Current knowledge now makes it possible to distinguish between at least seven major genetic subgroups of MDS and AML, and has directed research towards more specific causative factors also for de novo MDS and AML.
引用
收藏
页码：2177 / 2184
页数：8
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