The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey

被引：100

作者：

Rainero, Innocenzo ^{[1
,2
]}

Bruni, Amalia C. ^{[3
]}

Marra, Camillo ^{[4
]}

Cagnin, Annachiara ^{[5
]}

Bonanni, Laura ^{[6
]}

Cupidi, Chiara ^{[7
]}

Lagana, Valentina ^{[3
]}

Rubino, Elisa ^{[2
]}

Vacca, Alessandro ^{[1
]}

Di Lorenzo, Raffaele ^{[3
]}

Provero, Paolo ^{[8
,9
]}

Isella, Valeria ^{[10
,11
]}

Vanacore, Nicola ^{[12
]}

Agosta, Federica ^{[13
,14
,15
]}

Appollonio, Ildebrando ^{[10
,11
]}

Caffarra, Paolo ^{[16
]}

Busse, Cinzia ^{[5
]}

Sambati, Renato ^{[17
,18
]}

Quaranta, Davide ^{[4
]}

Guglielmi, Valeria ^{[4
]}

Logroscino, Giancarlo ^{[17
,18
]}

Filippi, Massimo ^{[13
,14
,15
]}

Tedeschi, Gioacchino ^{[19
]}

Ferrarese, Carlo ^{[10
,11
]}

机构：

[1] Univ Turin, Dept Neurosci Rita Levi Montalcini, Aging Brain & Memory Clin, Turin, Italy

[2] AOU Citta Salute & Sci Torino, Dept Neurosci & Mental Hlth, Turin, Italy

[3] ASP CZ, Dept Primary Care, Reg Neurogenet Ctr, Catanzaro, Italy

[4] Univ Cattolica Sacro Cuore, Memory Clin, Fdn Policlin Agostino Gemelli, IRCCS, Rome, Italy

[5] Univ Padua, Dept Neurosci, Padua, Italy

[6] Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy

[7] AUSL Ferrara, CDCD Osped Delta, Ferrara, Italy

[8] Univ Turin, Dept Neurosci Rita Levi Montalcini, Turin, Italy

[9] S Raffaele Sci Inst, IRCCS, Ctr Om Sci, Milan, Italy

[10] Univ Milano Bicocca, Dept Med & Surg, Monza, Italy

[11] Univ Milano Bicocca, Milan Ctr Neurosci NeuroMi, Monza, Italy

[12] Natl Inst Hlth, Rome, Italy

[13] Ist Sci San Raffaele, IRCCS, Div Neurosci, Neuroimaging Res Unit, Milan, Italy

[14] Univ Vita Salute San Raffaele, Neurol Unit, Neurorehabil Unit, Milan, Italy

[15] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, IRCCS, Neurophysiol Serv, Milan, Italy

[16] Univ Parma, Unit Neurosci, Parma, Italy

[17] Univ Bari, Dept Clin Res Neurol, Ctr Neurodegenerat Dis & Aging Brain, Bari, Italy

[18] Univ Bari Aldo Moro, Dept Basic Med Neurosci & Sense Organs, Bari, Italy

[19] Univ Campania L Vanvitelli, Dept Med & Surg Sci, Naples, Italy

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2021年 / 12卷

关键词：

quarantine; COVID-19; dementia; Alzheimer's disease; BPSD; caregiver burden; ALZHEIMERS-DISEASE; OLDER-ADULTS; SARS; STRESS; BURDEN;

D O I：

10.3389/fnagi.2020.625781

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Introduction: Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of quarantine for COVID-19 pandemic in patients with dementia are unknown. We investigated the clinical changes in patients with Alzheimer's disease and other dementias, and evaluated caregivers' distress during COVID-19 quarantine. Methods: The study involved 87 Italian Dementia Centers. Patients with Alzheimer's Disease (AD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementia (FTD), and Vascular Dementia (VD) were eligible for the study. Family caregivers of patients with dementia were interviewed by phone in April 2020, 45 days after quarantine declaration. Main outcomes were patients' changes in cognitive, behavioral, and motor symptoms. Secondary outcomes were effects on caregivers' psychological features. Results: 4913 patients (2934 females, 1979 males) fulfilled the inclusion criteria. Caregivers reported a worsening in cognitive functions in 55.1% of patients, mainly in subjects with DLB and AD. Aggravation of behavioral symptoms was observed in 51.9% of patients. In logistic regression analysis, previous physical independence was associated with both cognitive and behavioral worsening (odds ratio 1.85 [95% CI 1.42-2.39], 1.84 [95% CI 1.43-2.38], respectively). On the contrary, pandemic awareness was a protective factor for the worsening of cognitive and behavioral symptoms (odds ratio 0.74 [95% CI 0.65-0.85]; and 0.72 [95% CI 0.63-0.82], respectively). Approximately 25.9% of patients showed the onset of new behavioral symptoms. A worsening in motor function was reported by 36.7% of patients. Finally, caregivers reported a high increase in anxiety, depression, and distress. Conclusion: Our study shows that quarantine for COVID-19 is associated with an acute worsening of clinical symptoms in patients with dementia as well as increase of caregivers' burden. Our findings emphasize the importance to implement new strategies to mitigate the effects of quarantine in patients with dementia.

引用

页数：13

共 37 条

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