A clinical review of breast involvement in acute leukemia

被引:39
作者
Cunningham, Isabel [1 ]
机构
[1] Columbia Univ Coll Phys & Surg, Div Hematol & Med Oncol, New York, NY 10032 USA
关键词
extramedullary relapse; breast; relapse; granulocytic sarcoma; leukemia;
D O I
10.1080/10428190600967022
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The breast continues to be reported as a site of resistant leukemia despite current curative protocols. To characterize disease behavior and potential for lengthy survival after breast relapse, a study was undertaken of 153 cases reported between 1969 and 2005. Authors were contacted for follow-up. There were 105 AML and 48 ALL cases identified. Ninety percent of female patients were younger than 50 and leukemia was temporally related to pregnancy in 13. Eight cases were males. Remissions were typically of short duration, principally due to further extramedullary relapses, in 3 main sites in both AML and ALL: contralateral breast, gynecologic organs, and CNS. However, there are cases of disease-free survival up to 26+ years after intensive treatment. Leukemia growing in the breast may follow a distinctive pattern, and prompt initiation of intensive multi-cycle treatment, assuming occult site involvement, with consideration of CSF prophylaxis, should increase the potential for disease eradication.
引用
收藏
页码:2517 / 2526
页数:10
相关论文
共 168 条
[1]  
ABE R, 1986, CANCER, V58, P1260, DOI 10.1002/1097-0142(19860915)58:6<1260::AID-CNCR2820580614>3.0.CO
[2]  
2-O
[3]   Late onset Epstein-Barr virus-associated lymphoproliferative disease after allogeneic bone marrow transplant presenting as breast masses [J].
Abhyankar, SH ;
Chiang, KY ;
McGuirk, JP ;
Pati, AR ;
Godder, KT ;
Welsh, JA ;
Waldron, RL ;
McElveen, JL ;
Henslee-Downey, PJ .
BONE MARROW TRANSPLANTATION, 1998, 21 (03) :295-297
[4]  
Ahrar K, 1998, J ULTRAS MED, V17, P383
[5]   PELVIC AND MAMMARY BURKITT-LIKE LYMPHOMA WITH SIMULTANEOUS DEVELOPMENT OF LEUKEMIA [J].
AMADORI, G ;
BRIGATO, G ;
CORDIANO, V ;
MILANO, AS ;
MORETTO, F ;
SPANDRI, P ;
BECAGLI, L ;
DESALVIA, D .
GYNECOLOGIC ONCOLOGY, 1987, 26 (02) :246-250
[6]   Multiple relapses and extramedullary localization with scalp and breast involvement in a case of acute promyelocytic leukaemia [J].
Ammatuna, E ;
Borza, PA ;
Iori, AP ;
Petti, MC ;
Pescarmona, E ;
Diverio, D ;
Lo-Coco, F .
LEUKEMIA, 2005, 19 (03) :479-480
[7]   Chloroma (granulocytic sarcoma, myeloblastoma) -: Clinics and radiologic findings. [J].
Anders, M ;
Düber, C ;
Teifke, A ;
Gamm, H .
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, 2000, 172 (03) :282-286
[8]  
ANDERSON C D, 1954, Glasgow Med J, V35, P95
[9]  
Astruc J, 1970, J MED MONTPELLIER, V5, P445
[10]   Recurrent isolated extramedullary relapses as granulocytic sarcomas following allogeneic bone marrow transplantation for acute myeloid leukemia [J].
Au, WY ;
Chan, ACL ;
Lie, AKW ;
Chen, FE ;
Liang, R ;
Kwong, YL .
BONE MARROW TRANSPLANTATION, 1998, 21 (02) :205-208