Enantioseparation of benazepril intermediates by high-performance liquid chromatography on chiral CDMPC column

被引：0

作者：

Chen, Juanjuan ^{[1
]}

Shen, Baochun ^{[1
]}

Zhang, Xuejun ^{[1
]}

Xu, Xiuzhu ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

ANALYTICAL LETTERS | 2007年 / 40卷 / 01期

关键词：

CDMPC; benazepril intermediates; enantioseparation; HPLC;

D O I：

10.1080/00032710600952630

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A HPLC method was developed for resolutions of two benazepril intermediates. The separation was achieved on CDMPC. The influence of kinds of alcoholic modifiers, concentration of n-butanol and column temperature was studied for the optimization of resolutions. The best separation was achieved using 10% n-butanol as modifier and at 25 degrees C with alpha-value of 1.84 for BTB-C and 1.34 for BTB. The chiral recognition mechanism of CDMPC was explored. Hydrogen-bonding interaction and inclusion and fitness of solute in the chiral cavity significantly play an important role influencing the chiral separation, and the polarities of the alcohols have effect on the stereoselectivity too.

引用

页码：173 / 182

页数：10

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