Primary cortical brain cells influence osteoblast activity

被引：4

作者：

Anissian, Lucas ^{[1
]}

Kirby, Michael ^{[2
]}

Stark, Andre ^{[3
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Orthopaed Surg, Shreveport, LA 71130 USA

[2] Loma Linda Univ, Dept Pediat Pathol & Human Anat, Loma Linda, CA 92350 USA

[3] Karolinska Univ Hosp, Dept Orthopaed Surg, Stockholm, Sweden

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 390卷 / 03期

关键词：

Osteoblast; Bone turn-over; Brain cells; Fracture healing; NERVE GROWTH-FACTOR; BONE-FORMATION; FRACTURE; RAT; EXPRESSION; RECEPTORS; INNERVATION; INGROWTH; LEPTIN;

D O I：

10.1016/j.bbrc.2009.09.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of neuropeptides and neuroreceptors in the bone have been reported in several studies. Bone turn-over seems to be controlled by the nervous system. The actual pathway or the control mechanism is still under investigation. In this study we investigate the changes in osteoblast cells if they are in co-culture with primary cortical brain cells. After seven days in co-culture with the primary fetal brain cells the osteoblast cells exhibited hypertrophic morphological changes and showed stronger ALP activity. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：410 / 414

页数：5

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