Targeted and stimuli-responsive mesoporous silica nanoparticles for drug delivery and theranostic use

被引：44

作者：

Aquib, Md ^{[1
]}

Farooq, Muhammad A. ^{[1
]}

Banerjee, Parikshit ^{[1
]}

Akhtar, Fahad ^{[2
]}

Filli, Mensura S. ^{[1
]}

Boakye-Yiadom, Kofi O. ^{[1
]}

Kesse, Samuel ^{[1
]}

Raza, Faisal ^{[1
]}

Maviah, Mily B. J. ^{[1
]}

Mavlyanova, Rukhshona ^{[1
]}

Wang, Bo ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Nanjing 211198, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing, Jiangsu, Peoples R China

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2019年 / 107卷 / 12期

关键词：

biocompatibility; chemotherapeutics; cytotoxicity; functionalization; mesoporous silica nanoparticles; IN-VIVO; CONTROLLED-RELEASE; MULTIFUNCTIONAL NANOPARTICLES; CANCER-CELLS; LOGIC GATE; PARTICLES; NANOCARRIERS; SYSTEM; BIODISTRIBUTION; NANOMEDICINE;

D O I：

10.1002/jbm.a.36770

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

For cancer therapy, the usefulness of mesoporous silica nanoparticles (MPSNPs) has been widely discussed, likely due to its inorganic nature and excellent structural features. The MPSNPs-based chemotherapeutics have been promisingly delivered to their target sites that help to minimize side effects and improve therapeutic effectiveness. A wide array of studies have been conducted to functionalize drug-loaded MPSNPs using targeting ligands and stimuli-sensitive substances. In addition, anticancer drugs have been precisely delivered to their target sites using MPSNPs, which respond to multi-stimuli. Furthermore, MPSNPs have been extensively tested for their safety and compatibility. The toxicity level of MPSNPs is substantially lower as compared to that of colloidal silica; however, in oxidative stress, they exhibit cytotoxic features. The biocompatibility of MPSNPs can be improved by modifying their surfaces. This article describes the production procedures, functionalization, and applications of biocompatible MPSNPs in drug delivery.

引用

页码：2643 / 2666

页数：24

共 169 条

[1] Hybrid Nanomaterials Based on Iron Oxide Nanoparticles and Mesoporous Silica Nanoparticles: Overcoming Challenges in Current Cancer Treatments [J].