Straightforward and Stereoselective Synthesis of α,β-Diamino Acid Derivatives by Means of an Organocatalyzed Decarboxylative Mannich Reaction

被引：12
作者：
Singjunla, Yuttapong [1 ]
Baudoux, Jerome [1 ]
Rouden, Jacques [1 ]
机构：
[1] Normandie Univ, LCMT, ENSICAEN, UNICAEN,CNRS, 6 Blvd Marechal Juin, F-14000 Caen, France
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 22期
关键词：
Diastereoselectivity; Organocatalysis; Decarboxylation; Mannich reaction; Synthetic methods; RESISTANT ENTEROCOCCI VRE; BETA-AMINO ESTERS; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; GLYCOPEPTIDE ANTIBIOTICS; BIOLOGICAL SIGNIFICANCE; DESIGN; ANTRIMYCIN; ACCESS; (2S; 3R)-CAPREOMYCIDINE;
D O I：
10.1002/ejoc.201700468
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rapid and convenient method has been developed for the stereoselective synthesis of alpha,beta-diamino acid derivatives from amido-substituted malonic acid half oxyesters (MAHOs) and imines. The anti products were obtained with a diastereomeric ratio up to 99: 1 by using a decarboxylative Mannich reaction catalyzed by commercially available 1,4-diazabicyclo[2.2.2] octane (DABCO).
引用
收藏
页码：3240 / 3243
页数：4
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