Management of Hyperglycemic Crises Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State

被引：138

作者：

Fayfman, Maya ^{[1
]}

Pasquel, Francisco J. ^{[1
]}

Umpierrez, Guillermo E. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Div Endocrinol & Metab, 69 Jesse Hill Jr Dr Southeast,2nd Floor, Atlanta, GA 30303 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2017年 / 101卷 / 03期

关键词：

Hyperglycemic emergencies; Diabetic ketoacidosis; Hyperglycemic hyperosmolar state; Management of hyperglycemic emergencies; Diabetes; INTRAVENOUS REGULAR INSULIN; RETROSPECTIVE COHORT; BICARBONATE THERAPY; OXIDATIVE STRESS; CEREBRAL EDEMA; ADULT PATIENTS; KETONE-BODIES; TYPE-1; CHILDREN; RISK;

D O I：

10.1016/j.mcna.2016.12.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are the most serious and life-threatening hyperglycemic emergencies in diabetes. DKA is more common in young people with type 1 diabetes and HHS in adult and elderly patients with type 2 diabetes. Features of the 2 disorders with ketoacidosis and hyperosmolality may coexist. Both are characterized by insulinopenia and severe hyperglycemia. Early diagnosis and management are paramount. Treatment is aggressive rehydration, insulin therapy, electrolyte replacement, and treatment of underlying precipitating events. This article reviews the epidemiology, pathogenesis, diagnosis, and management of hyperglycemic emergencies.

引用

页码：587 / +

页数：21

共 124 条

[41] Failure of adjunctive bicarbonate to improve outcome in severe pediatric diabetic ketoacidosis [J].

Green, SM ;

Rothrock, SG ;

Ho, JD ;

Gallant, RD ;

Borger, R ;

Thomas, TL ;

Zimmerman, GJ .

ANNALS OF EMERGENCY MEDICINE, 1998, 31 (01) :41-48

[42]

Gregg EW, 2014, NEW ENGL J MED, V371, P286, DOI 10.1056/NEJMc1406009

[43] Diabetic ketoacidosis in pregnancy tends to occur at lower blood glucose levels: Case-control study and a case report of euglycemic diabetic ketoacidosis in pregnancy [J].

Guo, Rui-Xia ;

Yang, Ling-Zhu ;

Li, Liu-Xia ;

Zhao, Xue-Ping .

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2008, 34 (03) :324-330

[44] IMPACT OF A HYPERGLYCEMIC CRISES PROTOCOL [J].

Hara, Jayme S. ;

Rahbar, Aryan J. ;

Jeffres, Meghan N. ;

Izuora, Kenneth E. .

ENDOCRINE PRACTICE, 2013, 19 (06) :953-962

[45]

Hindle R, 1845, Prov Med Surg J, V9, P452

[46]

Hipszer Brian, 2005, Diabetes Technol Ther, V7, P83, DOI 10.1089/dia.2005.7.83

[47] Inflammatory mediators and blood brain barrier disruption in fatal brain edema of diabetic ketoacidosis [J].

Hoffman, William H. ;

Stamatovic, Svetlana M. ;

Andjelkovic, Anuska V. .

BRAIN RESEARCH, 2009, 1254 :138-148

[48] Subcutaneous Administration of Glargine to Diabetic Patients Receiving Insulin Infusion Prevents Rebound Hyperglycemia [J].

Hsia, Elisa ;

Seggelke, Stacey ;

Gibbs, Joanna ;

Hawkins, R. Matthew ;

Cohlmia, Elizabeth ;

Rasouli, Neda ;

Wang, Cecilia ;

Kam, Igal ;

Draznin, Boris .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (09) :3132-3137

[49] Long-term Mortality Risk After Hyperglycemic Crisis Episodes in Geriatric Patients With Diabetes: A National Population-Based Cohort Study [J].

Huang, Chien-Cheng ;

Weng, Shih-Feng ;

Tsai, Kang-Ting ;

Chen, Ping-Jen ;

Lin, Hung-Jung ;

Wang, Jhi-Joung ;

Su, Shih-Bin ;

Chou, Willy ;

Guo, How-Ran ;

Hsu, Chien-Chin .

DIABETES CARE, 2015, 38 (05) :746-751

[50] Diabetic ketoacidosis charges relative to medical charges of adult patients with type I diabetes [J].

Javor, KA ;

Kotsanos, JG ;

McDonald, RC ;

Baron, AD ;

Kesterson, JG ;

Tierney, WM .

DIABETES CARE, 1997, 20 (03) :349-354

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