Focal Adhesion Proteins α- and β-Parvin are Overexpressed in Human Colorectal Cancer and Correlate with Tumor Progression

This study aims to address the role of focal adhesion proteins - and -parvin in human colorectal carcinoma (CRC). Expression of - and -parvin was examined by immunohisto- chemistry and real-time RT-PCR in a series of human CRC. Parvins were overexpressed in CRC and their expression correlated significantly with tumor invasion, lymph node metastasis, and disease stage. A significant positive correlation of parvins protein expression with overexpression of integrin-linked kinase, p-AKT, and nuclear -catenin, as well as with downregulation of E-cadherin was also observed. In conclusion, overexpression of - and -parvin seems to be implicated in human colorectal cancer progression.