Sex differences in demographic and clinical characteristics of psychogenic nonepileptic seizures: A retrospective multicenter international study

被引：16

作者：

Asadi-Pooya, Ali A. ^{[1
,2
]}

Myers, Lorna ^{[3
]}

Valente, Kette ^{[4
]}

Restrepo, Anilu Daza ^{[5
]}

D'Alessio, Luciana ^{[6
,7
]}

Sawchuk, Tyson ^{[8
,9
]}

Homayoun, Maryam ^{[1
]}

Bahrami, Zahra ^{[1
]}

Alessi, Ruda ^{[4
]}

Paytan, Angelica Aroni ^{[5
]}

Kochen, Silvia ^{[6
,7
]}

Buchhalter, Jeffrey ^{[8
,10
]}

Taha, Firas ^{[3
]}

Lazar, Lorraine M. ^{[3
]}

Pick, Susannah ^{[11
]}

Nicholson, Imothy ^{[11
]}

机构：

[1] Shiraz Univ Med Sci, Shiraz Med Sch, Shiraz, Iran

[2] Thomas Jefferson Univ, Dept Neurol, Jefferson Comprehens Epilepsy Ctr, Philadelphia, PA 19107 USA

[3] Northeast Reg Epilepsy Grp, New York, NY USA

[4] Univ Sao Paulo, Fac Med, Hosp Clin, Inst Psychiat, Sao Paulo, Brazil

[5] La Trinidad Med Ctr, Epilepsy Unit, Caracas, Venezuela

[6] Buenos Aires Univ, Epilepsy Ctr, Ramos Mejia Hosp, ENyS IBCN CONICFT, Buenos Aires, DF, Argentina

[7] Buenos Aires Univ, Epilepsy Ctr, El Cruce Hosp, ENyS IBCN CONICFT, Buenos Aires, DF, Argentina

[8] Alberta Childrens Prov Gen Hosp, Childrens Comprehens Epilepsy Ctr, Calgary, AB, Canada

[9] Univ Nicosia, Sch Social Sci, Dept Psychol, Nicosia, Cyprus

[10] Univ Calgary, Cumming Sch Med, Dept Pediat, Calgary, AB, Canada

[11] Kings Coll London, Inst Psychiat Psychol & Neurosci, Sect Cognit Neuropsychiat, London, England

来源：

EPILEPSY & BEHAVIOR | 2019年 / 97卷

关键词：

International; PNES; Psychogenic; Seizure; Sex; GENDER-DIFFERENCES; CHILDHOOD MALTREATMENT; UNCONTROLLED SEIZURES; REASONS; TRAUMA; IMPACT; ABUSE;

D O I：

10.1016/j.yebeh.2019.05.045

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Purpose: Sex-related differences have been reported in patients with neurological and psychiatric disorders. It is also plausible to assume that there might be differences between females and males with psychogenic nonepileptic seizures (PNES). Methods: In this retrospective study, we investigated patients with PNES, who were admitted to the epilepsy monitoring units at centers in Iran, the USA, Canada, Brazil, Argentina, and Venezuela. Age, sex, age at seizure onset, seizure semiology, factors potentially predisposing to PNES, and video-electroencephalography recording of all patients were registered routinely. Results: Four hundred and fifty-one patients had PNES-only and were eligible for inclusion; 305 patients (67.6%) were females. We executed a logistic regression analysis, evaluating significant variables in univariate analyses (i.e., age, age at onset, aura, presence of historical sexual or physical abuse, and family dysfunction). The only variables retaining significance were historical sexual abuse (p = 0.005) and presence of aura (p = 0.01); physical abuse was borderline significant (p = 0.05) (all three were more prevalent among females). Conclusion: Similarities between females and males outweigh the differences with regard to the demographic and clinical characteristics of PNES. However, notable differences are that females more often report lifetime adverse experiences (sexual and probably physical abuse) and auras. While social, psychological, and genetic factors may interact with lifetime adverse experiences in the inception of PNES, the link is not yet clear. This is an interesting avenue for future studies. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：154 / 157

页数：4

共 22 条

[1] Psychogenic nonepileptic seizures are predominantly seen in women: potential neurobiological reasons [J].