Endogenous nitric oxide production and atrial natriuretic peptide biological activity in infants undergoing cardiac operations

被引:33
作者
Seghaye, MC
Duchateau, J
Bruniaux, J
Demontoux, S
Detruit, H
Bosson, C
Lecronier, G
Mokhfi, E
Serraf, A
Planche, C
机构
[1] CTR CHIRURG MARIE LANNELONGUE,EXPT SURG LAB,PARIS,FRANCE
[2] CTR CHIRURG MARIE LANNELONGUE,DEPT PEDIAT CARDIAC SURG,PARIS,FRANCE
[3] CTR CHIRURG MARIE LANNELONGUE,DEPT PEDIAT INTENS CARE,PARIS,FRANCE
[4] FREE UNIV BRUSSELS,HOP UNIV BRUGMANN,DEPT IMMUNOL,B-1020 BRUSSELS,BELGIUM
[5] FREE UNIV BRUSSELS,UNIV HOSP ST PIERRE,DEPT IMMUNOL,BRUSSELS,BELGIUM
关键词
atrial natriuretic peptide; cardiac surgery; congenital heart disease; heart failure; infancy; nitric oxide; nitrites; nitrates; pulmonary hypertension;
D O I
10.1097/00003246-199706000-00026
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Objectives: To examine whether preoperative heart failure and cardiac surgery influence nitric oxide production and atrial natriuretic peptide (ANP) biological activity in infants and whether nitric oxide and ANP participate in the control of postoperative pulmonary vascular tone. Design: Prospective, clinical study. Setting: Tertiary pediatric cardiac intensive care unit in a referral cardiosurgical center, Patients: Nineteen infants (median age 4 months) undergoing cardiac surgery: 13 infants with ventricular or atrioventricular septal defect associated with heart failure and pulmonary hypertension (group 1); and six infants with tetralogy of Fallot, without heart failure (group 2), Interventions: Blood samples obtained from indwelling catheters or bypass circuit outlets, Measurements and Main Results: Nitrite and nitrate blood concentrations (as a marker for nitric oxide synthesis) and the molar ratio of cyclic guanosine 3',5'-monophosphate (cGMP) to ANP (as a marker for ANP biological activity) were determined before, during, and up to 24 hrs after cardiopulmonary bypass (CPB), In group 1 patients, these biological parameters were related to postoperative pulmonary arterial pressure, Preoperative nitrite and nitrate concentrations were higher in group 1 patients than in group 2 patients (p < .02), and this difference persisted during CPB. Nitrite and nitrate concentrations 24 hrs postoperatively were lower than preoperative values in group 1 patients (p < .05) and were unchanged in group 2 patients, An inverse correlation was observed postoperatively between nitrite and nitrate concentrations and systolic pulmonary arterial pressure (r(2) = 0.4, P < .05), Group 1 patients had a lower preoperative cGMP/AMP ratio than group 2 patients (p < .05), despite higher ANP levels (p < .005). The cGMP/ANP ratio decreased during CPB in both groups (p < .0001), and in group 2 patients, cGMP and ANP values remained below preoperative values less than or equal to 24 hrs postoperatively, A correlation was observed between ANP levels and systolic pulmonary arterial pressure 2 and 4 hrs postoperatively (r(2) = .4, p < .05, respectively), but no correlation was observed between ANP biological activity and postoperative pulmonary arterial pressure. Conclusions: Infants with heart failure and pulmonary hypertension have increased nitric oxide synthesis and decreased ANP biological activity; both phenomena may be involved in the pathophysiology of this clinical condition, CPB has no detectable effect on nitric oxide production but does decrease ANP biological activity, In patients with preoperative heart failure and pulmonary hypertension, endogenous nitric oxide appears to play a role in the control of postoperative pulmonary vascular tone.
引用
收藏
页码:1063 / 1070
页数:8
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