A microfluidic system for controlling reaction networks in time

被引:1044
作者
Song, H [1 ]
Tice, JD [1 ]
Ismagilov, RF [1 ]
机构
[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
关键词
analytical methods; kinetics; microfluidics; microreactors; reaction networks;
D O I
10.1002/anie.200390203
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Millisecond mixing and transport with no dispersion are achieved by unsteady flows induced in droplets of about 60 pL that travel through winding microfluidic channels (top). Fluorescence can be used to monitor mixing (bottom) or measure reaction rates. In principle, arbitrarily complex reaction networks can be created by combining and splitting streams of such droplets.
引用
收藏
页码:768 / 772
页数:5
相关论文
共 33 条
[1]   STIRRING BY CHAOTIC ADVECTION [J].
AREF, H .
JOURNAL OF FLUID MECHANICS, 1984, 143 (JUN) :1-21
[2]   A test case of correlation metric construction of a reaction pathway from measurements [J].
Arkin, A ;
Shen, PD ;
Ross, J .
SCIENCE, 1997, 277 (5330) :1275-1279
[3]   Micro total analysis systems. 2. Analytical standard operations and applications [J].
Auroux, PA ;
Iossifidis, D ;
Reyes, DR ;
Manz, A .
ANALYTICAL CHEMISTRY, 2002, 74 (12) :2637-2652
[4]  
Bird R B., 2002, Transportphenomena
[5]   An integrated nanoliter DNA analysis device [J].
Burns, MA ;
Johnson, BN ;
Brahmasandra, SN ;
Handique, K ;
Webster, JR ;
Krishnan, M ;
Sammarco, TS ;
Man, PM ;
Jones, D ;
Heldsinger, D ;
Mastrangelo, CH ;
Burke, DT .
SCIENCE, 1998, 282 (5388) :484-487
[6]   Analytic chemistry: Everyone's a (future) chemist [J].
Burns, MA .
SCIENCE, 2002, 296 (5574) :1818-1819
[7]   LAMINAR MIXING AND CHAOTIC MIXING IN SEVERAL CAVITY FLOWS [J].
CHIEN, WL ;
RISING, H ;
OTTINO, JM .
JOURNAL OF FLUID MECHANICS, 1986, 170 :355-377
[8]   Fluidics and sample handling in clinical chemical analysis [J].
Cunningham, DD .
ANALYTICA CHIMICA ACTA, 2001, 429 (01) :1-18
[9]   Coalescence of liquid drops [J].
Eggers, J ;
Lister, JR ;
Stone, HA .
JOURNAL OF FLUID MECHANICS, 1999, 401 :293-310
[10]   On-chip thermopneumatic pressure for discrete drop pumping [J].
Handique, K ;
Burke, DT ;
Mastrangelo, CH ;
Burns, MA .
ANALYTICAL CHEMISTRY, 2001, 73 (08) :1831-1838