The age-adjusted Charlson comorbidity index is an independent prognostic factor in pancreatic cancer patients who receive curative resection followed by adjuvant chemotherapy

被引：12

作者：

Aoyama, Toru ^{[1
,2
]}

Yamamoto, Naoto ^{[1
,2
]}

Kamiya, Mariko ^{[1
,2
]}

Murakawa, Masaaki ^{[1
,2
]}

Tamagawa, Hiroshi ^{[1
,2
]}

Sawazaki, Sho ^{[2
]}

Numata, Masakatsu ^{[2
]}

Kobayashi, Satoshi ^{[3
]}

Ueno, Makoto ^{[3
]}

Morimoto, Manabu ^{[3
]}

Shiozawa, Manabu ^{[1
]}

Yukawa, Norio ^{[2
]}

Oshima, Takashi ^{[2
]}

Yoshikawa, Takaki ^{[2
]}

Rino, Yasushi ^{[2
]}

Masuda, Munetaka ^{[2
]}

Morinaga, Soichiro ^{[1
,2
]}

机构：

[1] Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Yokohama, Kanagawa, Japan

[2] Yokohama City Univ, Dept Surg, Yokohama, Kanagawa, Japan

[3] Kanagawa Canc Ctr, Div Hepatobiliary & Pancreat Med Oncol, Dept Gastroenterol, Yokohama, Kanagawa, Japan

来源：

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | 2020年 / 16卷

关键词：

Age-adjusted Charlson comorbidity index; pancreatic cancer; survival; POSTOPERATIVE COMPLICATIONS; INFECTIOUS COMPLICATIONS; SURVIVAL; ADENOCARCINOMA; GEMCITABINE; STATISTICS; RECURRENCE; IMPACT; TRIAL;

D O I：

10.4103/jcrt.JCRT_440_18

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: We investigated the impact of the age-adjusted Charlson comorbidity index (ACCI) on the pancreatic cancer survival and recurrence after curative surgery followed by adjuvant chemotherapy. Patients and Methods: This study included 155 patients who underwent curative surgery followed by adjuvant chemotherapy for pancreatic cancer between 2005 and 2014. The risk factors for the overall survival (OS) and recurrence-free survival (RFS) were identified. Results: An ACCI of 8 was regarded as the optimum critical point of classification considering the 1-, 3- and 5-year survival rates. The OS rates at 3 and 5 years after surgery were 25.7% and 19.0% in the ACCI-low group, respectively, and 7.6% and 0% in the ACCI-high group, which amounted to a statistically significant difference (P = 0.019). The RFS rates at 3 and 5 years after surgery were 17.3% and 13.8% in the ACCI-low group, respectively, and 7.1% and 0% in the ACCI-high group, which amounted to a marginally statistically significant difference (P = 0.104). A multivariate analysis showed that the ACCI was a significant independent risk factor for both the OS and RFS. Conclusions: The ACCI was a risk factor for the OS in patients who underwent curative surgery followed by adjuvant chemotherapy for pancreatic cancer. An effective plan is needed for determining the optimum surgical strategy according to the ACCI.

引用

页码：S116 / S121

页数：6

共 28 条

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