Balance impairment in pediatric charcot-marie-tooth disease

被引：21

作者：

Estilow, Timothy ^{[1
]}

Glanzman, Allan M. ^{[1
]}

Burns, Joshua ^{[2
,3
]}

Harrington, Ann ^{[1
]}

Cornett, Kayla ^{[2
,3
]}

Menezes, Manoj P. ^{[2
,3
]}

Shy, Rosemary ^{[4
]}

Moroni, Isabella ^{[5
]}

Pagliano, Emanuela ^{[5
]}

Pareyson, Davide ^{[5
]}

Bhandari, Trupti ^{[6
,7
]}

Muntoni, Francesco ^{[6
,7
]}

Laura, Matilde ^{[8
]}

Reilly, Mary M. ^{[8
]}

Finkel, Richard S. ^{[9
]}

Eichinger, Kate J. ^{[10
]}

Herrmann, David N. ^{[10
]}

Troutman, Gregory ^{[11
]}

Bray, Paula ^{[2
,3
]}

Halaki, Mark ^{[12
]}

Shy, Michael E. ^{[12
]}

Yum, Sabrina W. ^{[13
]}

Cornett, Kayla M. D.

Menezes, Manoj P. ^{[2
,3
]}

Ouvrier, Robert

Acsadi, Gyula

Shy, Rosemary R.

Calabrese, Daniela

Foscan, Maria

Sala, Roberta

Moroni, Isabella ^{[5
]}

Pagliano, Emanuela ^{[5
]}

Pareyson, Davide ^{[5
]}

Estilow, Timothy ^{[1
]}

Yum, Sabrina W. ^{[13
]}

Bhandari, Trupti ^{[6
,7
]}

Muntoni, Francesco ^{[6
,7
]}

laura, MatilDe

Reilly, Mary M. ^{[8
]}

Finkel, Richard S. ^{[9
]}

Eichinger, Kate J. ^{[10
]}

Herrmann, David N. ^{[10
]}

Bray, Paula ^{[2
,3
]}

Rose, Kristy

Halaki, Mark ^{[12
]}

Pallant, Julie

Lek, Monkol

Shy, Michael E. ^{[12
]}

Burns, Joshua ^{[2
,3
]}

机构：

[1] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[2] Univ Sydney, Sydney, NSW, Australia

[3] Childrens Hosp Westmead, Sydney, NSW, Australia

[4] Univ Iowa, Dept Pediat, Carver Coll Med, Iowa City, IA 52242 USA

[5] IRCCS Fdn, Carlo Besta Neurol Inst, Milan, Italy

[6] UCL Inst Child Hlth, London, England

[7] Great Ormond St Hosp Sick Children, London, England

[8] UCL Inst Neurol, MRC Ctr Neuromuscular Dis, Queen Sq, London, England

[9] Nemours Childrens Hosp, Neuromuscular Program, Div Neurol, Orlando, FL USA

[10] Univ Rochester, Dept Neurol, Rochester, NY USA

[11] Univ Penn, Dept Biostat & Clin Epidemiol, Perelman Sch Med, Philadelphia, PA 19104 USA

[12] Univ Iowa, Dept Neurol, Carver Coll Med, Iowa City, IA 52242 USA

[13] Univ Penn, Childrens Hosp Philadelphia, Dept Neurol, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

MUSCLE & NERVE | 2019年 / 60卷 / 03期

关键词：

balance; Charcot-Marie-Tooth; children; intervention; sensorimotor impairment; FOOT POSTURE INDEX; 6-MINUTE WALK TEST; CMT NEUROPATHY SCORE; NATURAL-HISTORY; OUTCOME MEASURE; CHILDREN; RELIABILITY; VALUES; SWAY; VALIDATION;

D O I：

10.1002/mus.26500

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Balance impairment contributes to gait dysfunction, falls, and reduced quality of life in adults with Charcot-Marie-Tooth disease (CMT) but has been minimally examined in pediatric CMT. Methods: The CMT Pediatric Scale (CMTPedS) was administered to 520 children with CMT. Associations between balance function (Bruininks-Oseretsky Test of Motor Proficiency [BOT-2]) and sensorimotor and gait impairments were investigated. Results: Daily trips/falls were reported by 42.3% of participants. Balance (BOT-2) varied by CMT subtype, was impaired in 42% of 4-year-olds, and declined with age (P < 0.001). Vibration (P < 0.001), pinprick (P < 0.004), ankle dorsiflexion strength (P < 0.001), and foot alignment (P < 0.004) were associated with BOT-2 balance (adjusted R-2 = 0.28). The visual dependence of balance increased with age. Discussion: Balance impairment occurs from a young age in children with CMT. Balance intervention studies are required in pediatric CMT and should consider the degree of sensorimotor impairment, foot malalignment, and visual dependence. Muscle Nerve, 2019

引用

页码：242 / 249

页数：8

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