Dopamine/adenosine interactions involved in effort-related aspects of food motivation

被引：47
作者：
Salamone, John D. [1 ]
Correa, Merce [1 ,2 ]
机构：
[1] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA
[2] Univ Jaume 1, Area Psicobiol, Castellon de La Plana 12071, Spain
来源：
APPETITE | 2009年 / 53卷 / 03期
关键词：
Operant; Reinforcement; Motivation; Behavioral economics; Reward; Decision making; Activation; NUCLEUS-ACCUMBENS DOPAMINE; EFFORT-RELATED CHOICE; ADENOSINE A(2A) RECEPTORS; ALTER RESPONSE ALLOCATION; ANTAGONIST MSX-3 REVERSES; D-2; RECEPTORS; HALOPERIDOL; DEPLETIONS; BEHAVIOR; RATS;
D O I：
10.1016/j.appet.2009.07.018
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Nucleus accumbens dopamine (DA) is involved in effort-related aspects of food motivation. Accumbens DA depletions reduce the tendency of rats to work for food, and alter effort-related choice, but leave other aspects of food motivation and appetite intact. DA and adenosine receptors interact to regulate effort-related processes. Adenosine A(2A) antagonists can reverse the effects of DA D-2 antagonists on effort-related choice, and intra-accumbens injections of a adenosine A(2A) agonist produce effects that are similar to those produced by accumbens DA depletion or antagonism. These studies have implications for understanding the neurochemical interactions that underlie activational aspects of motivation. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：422 / 425
页数：4
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