Calcium-Independent Membrane Damage by Venom Phospholipases A2

被引：7
作者：
de Oliveira, A. H. C. [1 ]
Aragao, E. A. [1 ]
Sa, J. M. [2 ]
Chioato, L. [2 ]
Bugs-Bortoleto, R. [3 ]
Ruller, R. [1 ]
Ferreira, T. L. [2 ]
Ward, R. J. [1 ]
机构：
[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto, SP, Brazil
[2] Univ Sao Paulo, FMRP, Dept Bioquim & Immunol, BR-14040901 Ribeirao Preto, SP, Brazil
[3] Univ Estadual Sao Paulo, UNESP, IBILICE, Dept Fis, Sao Paulo, Brazil
来源：
PROTEIN AND PEPTIDE LETTERS | 2009年 / 16卷 / 08期
基金：
巴西圣保罗研究基金会;
关键词：
Membrane permeabilization; molecular mechanism; micelle nucleation; ASPER SNAKE-VENOM; AMINO-ACID-SEQUENCE; AGKISTRODON-PISCIVORUS-PISCIVORUS; MYOTOXIN-II; CRYSTAL-STRUCTURE; BOTHROPSTOXIN-I; PIRATOXIN-I; VIPERA-AMMODYTES; LYSINE-49; PHOSPHOLIPASE-A2; LYS(49)-PHOSPHOLIPASE A(2);
D O I：
10.2174/092986609788923392
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Many snake venom phospholipase A(2)s (vPLA(2)s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA(2)s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.
引用
收藏
页码：877 / 886
页数：10
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