Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials

被引：22

作者：

Grimberg, Brian T. ^{[1
]}

Jaworska, Maria M. ^{[2
]}

Hough, Lindsay B. ^{[3
]}

Zimmerman, Peter A. ^{[1
]}

Phillips, James G. ^{[2
]}

机构：

[1] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA

[2] Curragh Chem Inc, Sherwin Williams Cradle, Valley View, OH 44125 USA

[3] Albany Med Coll, Ctr Neuropharmacol & Neurosci, Albany, NY 12208 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 18期

关键词：

Cytometry; Malarial; Drug discovery; PARASITE PLASMODIUM-FALCIPARUM; IN-VITRO; CHLOROQUINE RESISTANCE; HEMOGLOBIN DEGRADATION; PROTEIN-KINASES; INHIBITORS; AMPLIFICATION; HALOFANTRINE; SENSITIVITY; MEFLOQUINE;

D O I：

10.1016/j.bmcl.2009.07.095

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new flow cytometry method that uses an optimized DNA and RNA staining strategy to monitor the growth and development of the Plasmodium falciparum strain W2mef has been used in a pilot study and has identified Bay 43-9006 1, SU 11274 2, and TMC 125 5 as compounds that exhibit potent (<1 mu M) overall and ring stage in vitro antimalarial activity. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5452 / 5457

页数：6

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