Humoral Mechanisms of Atherogenesis

被引：5

作者：

Batuca, Joana R. ^{[2
]}

Amaral, Marta C. ^{[1
,2
]}

Alves, J. Delgado ^{[1
,2
]}

机构：

[1] Curry Cabral Hosp, Autoimmune Dis Unit, Lisbon, Portugal

[2] Fac Ciencias Med, Dept Farmacol, P-1169056 Lisbon, Portugal

来源：

CONTEMPORARY CHALLENGES IN AUTOIMMUNITY | 2009年 / 1173卷

关键词：

humoral response; atherogenesis; anti-HSP antibodies; anti-oxLDL antibodies; anti-HDL antibodies; LOW-DENSITY-LIPOPROTEIN; SYSTEMIC-LUPUS-ERYTHEMATOSUS; PRIMARY ANTIPHOSPHOLIPID SYNDROME; HUMAN ATHEROSCLEROTIC PLAQUES; CORONARY-ARTERY-DISEASE; INTIMA-MEDIA THICKNESS; APOLIPOPROTEIN-A-I; RECEPTOR-DEFICIENT MICE; C-REACTIVE PROTEIN; OXIDIZED LDL;

D O I：

10.1111/j.1749-6632.2009.04747.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The concept that atherosclerosis is an autoimmune disease is no longer controversial. Attention has been paid to cellular immune response, but current research is now focused on the humoral component of this complex disease. Heat shock proteins, oxidized low-density lipoproteins, beta 2-glycoprotein 1, cardiolipins, and, more recently, high-density lipoproteins have been considered to be autoantigens that play a part in atherogenesis. The characterization and understanding of the mechanisms associated with the presence of these antigens and their respective autoantibodies might contribute to elucidating the atherosclerotic process. In the near future, immune modulation might constitute a very effective therapy of atherosclerosis.

引用

页码：401 / 408

页数：8

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