Lipid Nanoparticles for Drug Delivery to the Brain: In Vivo Veritas

被引：23
作者：
Blasi, Paolo [1 ]
Schoubben, Aurelie [1 ]
Giovagnoli, Stefano [1 ]
Rossi, Carlo [1 ]
Ricci, Maurizio [1 ]
机构：
[1] Univ Perugia, Dept Chem & Technol Drugs, Sch Pharm, I-06123 Perugia, Italy
来源：
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2009年 / 5卷 / 04期
关键词：
Brain Drug Delivery; Blood-Brain Barrier (BBB); Neurovascular Unit (NVU); Colloids; Lipid Colloidal Dispersions; Solid Lipid Nanoparticles (SLN); TISSUE DISTRIBUTION; MEDIATED TRANSPORT; PROTEIN ADSORPTION; BARRIER TRANSPORT; BODY DISTRIBUTION; PLASMA-PROTEINS; NON-STEALTH; SLN; PHARMACOKINETICS; SYSTEM;
D O I：
10.1166/jbn.2009.1043
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The present article is not aimed at extensively reviewing the literature on lipid nanoparticles, already described in monographs of recent redaction, but will provide a compilation of in vivo evidences supporting their potentiality in overcoming the blood-brain barrier problem. The advantages of using lipid over polymer carriers will be also discussed.
引用
收藏
页码：344 / 350
页数：7
相关论文
共 85 条
[51]   Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations [J].
Müller, RH ;
Radtke, M ;
Wissing, SA .
ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 :S131-S155
[52]   Challenges and solutions for the delivery of biotech drugs - a review of drug nanocrystal technology and lipid nanoparticles [J].
Muller, RH ;
Keck, CM .
JOURNAL OF BIOTECHNOLOGY, 2004, 113 (1-3) :151-170
[53]   Solid lipid nanoparticles (SLN) for controlled drug delivery -: a review of the state of the art [J].
Müller, RH ;
Mäder, K ;
Gohla, S .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2000, 50 (01) :161-177
[54]  
MULLER RH, 1989, BIOADHESION POSSIBIL, P202
[55]  
Muller RH, 2002, NEW DRUGS, V2, P38
[56]  
Muller RH., 2004, Encyclopedia of Nanoscience and Nanotechnology, P43
[57]   Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate [J].
Olbrich, C ;
Gessner, A ;
Kayser, O ;
Müller, RH .
JOURNAL OF DRUG TARGETING, 2002, 10 (05) :387-396
[58]   Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity [J].
Olivier, JC ;
Fenart, L ;
Chauvet, R ;
Pariat, C ;
Cecchelli, R ;
Couet, W .
PHARMACEUTICAL RESEARCH, 1999, 16 (12) :1836-1842
[59]  
Pardridge W.M., 2001, BRAIN DRUG TARGETING
[60]  
Pardridge William M, 2003, Mol Interv, V3, P90, DOI 10.1124/mi.3.2.90
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