Lipid Nanoparticles for Drug Delivery to the Brain: In Vivo Veritas

被引：23
作者：
Blasi, Paolo [1 ]
Schoubben, Aurelie [1 ]
Giovagnoli, Stefano [1 ]
Rossi, Carlo [1 ]
Ricci, Maurizio [1 ]
机构：
[1] Univ Perugia, Dept Chem & Technol Drugs, Sch Pharm, I-06123 Perugia, Italy
来源：
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2009年 / 5卷 / 04期
关键词：
Brain Drug Delivery; Blood-Brain Barrier (BBB); Neurovascular Unit (NVU); Colloids; Lipid Colloidal Dispersions; Solid Lipid Nanoparticles (SLN); TISSUE DISTRIBUTION; MEDIATED TRANSPORT; PROTEIN ADSORPTION; BARRIER TRANSPORT; BODY DISTRIBUTION; PLASMA-PROTEINS; NON-STEALTH; SLN; PHARMACOKINETICS; SYSTEM;
D O I：
10.1166/jbn.2009.1043
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The present article is not aimed at extensively reviewing the literature on lipid nanoparticles, already described in monographs of recent redaction, but will provide a compilation of in vivo evidences supporting their potentiality in overcoming the blood-brain barrier problem. The advantages of using lipid over polymer carriers will be also discussed.
引用
收藏
页码：344 / 350
页数：7
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