Putting chirality to work: The strategy of chiral switches

被引：498
|
作者：
Agranat, I
Caner, H
Caldwell, A
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Div Biomed Sci, London SW7 2AZ, England
[2] Hebrew Univ Jerusalem, Dept Organ Chem, IL-91904 Jerusalem, Israel
来源：
NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 10期
关键词：
D O I：
10.1038/nrd915
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Most of the new drugs reaching the market today are single enantiomers, rather than the racemic mixtures that dominated up to ten years ago. Many of the new single-enantiomer drugs were developed as such, but there are also important examples of new single-enantiomer drugs derived from 'chiral switches' of established racemates. Indeed, a well-timed chiral switch can offer enhanced therapy and further profitability as a 'line extension' of a major racemic drug with patents that are expiring.
引用
收藏
页码：753 / 768
页数：16
相关论文
共 50 条
  • [1] Putting chirality to work: the strategy of chiral switches
    Israel Agranat
    Hava Caner
    John Caldwell
    Nature Reviews Drug Discovery, 2002, 1 : 753 - 768
  • [2] The Death of the Strategy of Classical Chiral Switches Is an Exaggeration
    Agranat, Israel
    D'Acquarica, Ilaria
    ACS MEDICINAL CHEMISTRY LETTERS, 2024, 15 (11): : 1797 - 1801
  • [3] Helical Chirality of Azobenzenes Induced by an Intramolecular Chiral Axis and Potential as Chiroptical Switches
    Takaishi, Kazuto
    Kawamoto, Masuki
    Tsubaki, Kazunori
    Furuyama, Taniyuki
    Muranaka, Atsuya
    Uchiyama, Masanobu
    CHEMISTRY-A EUROPEAN JOURNAL, 2011, 17 (06) : 1778 - 1782
  • [4] Catalytic asymmetric sulfoxidation by chiral manganese complexes:: Acetylacetonate anions as chirality switches
    Schoumacker, S
    Hamelin, O
    Pécaut, J
    Fontecave, M
    INORGANIC CHEMISTRY, 2003, 42 (24) : 8110 - 8116
  • [5] From stories to strategy: Putting organizational learning to work
    Bennet, Alex
    Bennet, David
    VINE, 2007, 37 (04): : 404 - 409
  • [6] Chiral switches
    Tucker, GT
    LANCET, 2000, 355 (9209): : 1085 - 1087
  • [7] Dynamic chirality, chirality transfer and aggregation behaviour of dithienylethene switches
    de Jong, Jaap J. D.
    van Rijn, Patrick
    Tiemersma-Wegeman, Theodora D.
    Lucas, Linda N.
    Browne, Wesley R.
    Kellogg, Richard M.
    Uchida, Kingo
    Van Esch, Jan H.
    Feringa, Ben L.
    TETRAHEDRON, 2008, 64 (36) : 8324 - 8335
  • [8] Enantioselective Recognition of Chiral Tryptophan with Achiral Glycine through the Strategy of Chirality Transfer
    Wu, Shanshan
    Ye, Qiumin
    Wu, Datong
    Tao, Yongxin
    Kong, Yong
    ANALYTICAL CHEMISTRY, 2020, 92 (17) : 11927 - 11934
  • [9] Chirality at work
    Rouhi, AM
    CHEMICAL & ENGINEERING NEWS, 2003, 81 (18) : 56 - 61
  • [10] The Quest for Secondary Pharmaceuticals: Drug Repurposing/Chiral-Switches Combination Strategy
    D'Acquarica, Ilaria
    Agranat, Israel
    ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2023, 6 (02) : 201 - 219
12345