Role of Ultrasound in Anti-Cancer Drug Delivery Loaded on Microspheres

This study investigate the role of ultrasound in anticancer drug delivery loaded on microspheres The 5-flurouracil (5-FU) chitosan microparticles was prepared by the chemical cross-linking method. A total of 80 male Swiss albino mice weighting (20-25 g) received Subcutaneous injections of 2x10(6) (Ehrlich ascites carcinoma) cells mammary in origin. A week later, the tumor bearing mice were divided into four main groups: group of 20 mice serves as a control untreated group, group of 20 mice which were injected with 5-FU only, group of 20 mice which were injected with blank chitosan microspheres, and a group of 20 mice which were injected with 5-FU chitosan microspheres. Each group was divided into two subgroups each of 10 mice, where one group was treated with ultrasonic waves and the other subgroup received no treatment with ultrasonic waves. Calculations were made 14 days after treatment in order to compare the volumes, inhibition ratios of the tumors and survival curves of each group. Results obtained indicate that tumor volume delayed 28 days by combined treatment of 5-FU chitosan microparticles and ultrasound than that with 5-FU chitosan microparticles alone.