Roles of mucin-type O-glycans in cell adhesion

被引：114

作者：

Fukuda, M ^{[1
]}

机构：

[1] Burnham Inst, Glycobiol & Carbohydrate Chem Program, La Jolla, CA 92037 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2002年 / 1573卷 / 03期

关键词：

mucin-type O-glycan; Core2 branching beta 1,6-N-acetylglucosaminyltransferase; protein-protein interaction; carbohydrate-protein interaction;

D O I：

10.1016/S0304-4165(02)00409-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mucin-type O-glycans containing Core2 branches have distinctly different functions from those O-glycans that contain Core I structures. Core2 branched O-glycans can have terminal structures that function as ligands for carbohydrate binding proteins. However, sialylated Core2 branched O-glycans without additional modifications exhibit anti-adhesive properties. These results demonstrate that certain mucin-type O-glycans can either facilitate or attenuate cell adhesion depending on the core structures and the structures of the non-reducing termini. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：394 / 405

页数：12

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