Radical and Electron Recycling in Catalysis

被引：42

作者：

Buckel, Wolfgang ^{[1
,2
]}

机构：

[1] Univ Marburg, Fachbereich Biol, Mikrobiol Lab, D-35032 Marburg, Germany

[2] Max Planck Inst Terr Mikrobiol, Marburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 37期

关键词：

coenzymes; enzyme catalysis; radical enzymes; radicals; synthetic methods; PYRUVATE FORMATE-LYASE; CARBON SKELETON REARRANGEMENTS; COLI RIBONUCLEOTIDE REDUCTASE; CHORISMATE SYNTHASE REACTION; AMINO-ACID FERMENTATION; ENOYL-COA HYDRATASE; CRYSTAL-STRUCTURE; ESCHERICHIA-COLI; 4-HYDROXYBUTYRYL-COA DEHYDRATASE; ANAEROBIC-BACTERIA;

D O I：

10.1002/anie.200900771

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An increasing number of enzymes are being discovered that contain radicals or catalyze reactions via radical intermediates. These radical enzymes are able to open reaction pathways that two-electron steps cannot achieve. Recently, organic chemists started to apply related radical chemistry for synthetic purposes, whereby an electron energized by light is recycled in every turnover. This Minireview compares this new type of reaction with enzymes that use recycling radicals and single electrons as cofactors. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6779 / 6787

页数：9

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