Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q

被引：2
作者：
Wirtz, MK
Samples, JR
Kramer, PL
Rust, K
Topinka, JR
Yount, J
Koler, RD
Acott, TS
机构：
[1] OREGON HLTH SCI UNIV, CASEY EYE INST, DEPT MOL & MED GENET, PORTLAND, OR 97201 USA
[2] OREGON HLTH SCI UNIV, CASEY EYE INST, DEPT NEUROL, PORTLAND, OR 97201 USA
来源：
AMERICAN JOURNAL OF HUMAN GENETICS | 1997年 / 60卷 / 02期
关键词：
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Glaucoma is the third-leading cause of blindness in the world, affecting >13.5 million people. Adult-onset primary open-angle glaucoma (POAG) is the most common form of glaucoma in the United States. We present a family in which adult-onset POAG is inherited as an autosomal dominant trait. Twelve affected family members were identified from 44 at-risk individuals. The disease-causing gene was mapped to chromosome 3q21-24, with analysis of recombinant haplotypes suggesting a total inclusion region of 11.1 cM between markers D3S3637 and D3S1744. This is the first report of mapping of an adult-onset POAG gene to chromosome 3q, gene symbol GLC1C.
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页码：296 / 304
页数：9
相关论文
共 54 条
[41]   A COLLECTION OF TRINUCLEOTIDE AND TETRANUCLEOTIDE REPEAT MARKERS USED TO GENERATE HIGH-QUALITY, HIGH-RESOLUTION HUMAN GENOME-WIDE LINKAGE MAPS [J].
SHEFFIELD, VC ;
WEBER, JL ;
BUETOW, KH ;
MURRAY, JC ;
EVEN, DA ;
WILES, K ;
GASTIER, JM ;
PULIDO, JC ;
YANDAVA, C ;
SUNDEN, SL ;
MATTES, G ;
BUSINGA, T ;
MCCLAIN, A ;
BECK, J ;
SCHERPIER, T ;
GILLIAM, J ;
ZHONG, J ;
DUYK, GM .
HUMAN MOLECULAR GENETICS, 1995, 4 (10) :1837-1844
[42]  
Shieds M. B., 1996, GLAUCOMAS, P717
[43]  
SHIN DH, 1977, ARCH OPHTHALMOL-CHIC, V95, P598
[44]   HEMATOPOIETIC DIFFERENTIATION ANTIGENS THAT ARE MEMBRANE-ASSOCIATED ENZYMES - CUTTING IS THE KEY [J].
SHIPP, MA ;
LOOK, AT .
BLOOD, 1993, 82 (04) :1052-1070
[45]   ASSIGNMENT OF GENES ENCODING A UNIQUE CYTOKINE (IL12) COMPOSED OF 2 UNRELATED SUBUNITS TO CHROMOSOME-3 AND CHROMOSOME-5 [J].
SIEBURTH, D ;
JABS, EW ;
WARRINGTON, JA ;
LI, X ;
LASOTA, J ;
LAFORGIA, S ;
KELLEHER, K ;
HUEBNER, K ;
WASMUTH, JJ ;
WOLF, SF .
GENOMICS, 1992, 14 (01) :59-62
[46]  
SMITH DI, 1995, CYTOGENET CELL GENET, V68, P126
[47]   Localization of a locus (GLC1B) for adult-onset primary open angle glaucoma to the 2cen-q13 region [J].
Stoilova, D ;
Child, A ;
Trifan, OC ;
Crick, RP ;
Coakes, RL ;
Sarfarazi, M .
GENOMICS, 1996, 36 (01) :142-150
[48]  
SUZUKAWA K, 1994, BLOOD, V84, P2681
[49]  
TEIKARI JM, 1987, ACTA OPHTHALMOL, V65, P715
[50]   FAMILY HISTORY AND RISK OF PRIMARY OPEN-ANGLE GLAUCOMA - THE BALTIMORE EYE SURVEY [J].
TIELSCH, JM ;
KATZ, J ;
SOMMER, A ;
QUIGLEY, HA ;
JAVITT, JC .
ARCHIVES OF OPHTHALMOLOGY, 1994, 112 (01) :69-73
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