Significance of eukaryotic translation elongation factor 1A in tobacco mosaic virus infection

被引：43
|
作者：
Yamaji, Yasuyuki [1 ]
Sakurai, Keitaro [1 ]
Hamada, Koji [1 ]
Komatsu, Ken [1 ]
Ozeki, Johji [1 ]
Yoshida, Akiko [1 ]
Yoshii, Atsushi [1 ]
Shimizu, Takumi [1 ]
Namba, Shigetou [1 ]
Hibi, Tadaaki [2 ]
机构：
[1] Univ Tokyo, Plant Pathol Lab, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan
[2] Hosei Univ, Fac Biosci & Appl Chem, Tokyo, Japan
来源：
ARCHIVES OF VIROLOGY | 2010年 / 155卷 / 02期
基金：
日本学术振兴会;
关键词：
DEPENDENT RNA-POLYMERASE; FACTOR; 1-ALPHA; REPLICATION; PROTEIN; INTERACTS; FACTOR-1-ALPHA; TRANSCRIPTION; CYTOSKELETON; EXPRESSION; TRANSGENE;
D O I：
10.1007/s00705-009-0571-x
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Eukaryotic translation elongation factor 1A (eEF1A) has been shown to interact with both the viral RNA-dependent RNA polymerase and the 3'-terminal genomic RNA of tobacco mosaic virus (TMV). In this study, we demonstrated that the down-regulation of eEF1A mRNA levels by virus-induced gene silencing using potato virus X vector dramatically reduced the accumulation of TMV RNA and the spread of TMV infection. The translation activity of the eEF1A-silenced Nicotiana benthamiana leaves was not severely affected. Collectively, these results suggest an essential role of eEF1A in TMV infection.
引用
收藏
页码：263 / 268
页数：6
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