Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples

被引：40

作者：

Pascoal, Livia Bitencourt ^{[1
,2
]}

Rodrigues, Patricia Brito ^{[1
]}

Genaro, Livia Moreira ^{[2
]}

dos Santos Pereira Gomes, Arilson Bernardo ^{[1
]}

Toledo-Teixeira, Daniel Augusto ^{[3
]}

Parise, Pierina Lorencini ^{[3
]}

Bispo-Dos-Santos, Karina ^{[3
]}

Simeoni, Camila Lopes ^{[3
]}

Guimaraes, Paula Veri ^{[2
]}

Buscaratti, Lucas Ildefonso ^{[4
]}

De Angeli Elston, Joao Gabriel ^{[4
]}

Marques-Souza, Henrique ^{[4
]}

Martins-de-Souza, Daniel ^{[5
,6
]}

Setsuko Ayrizono, Maria De Lourdes ^{[2
]}

Velloso, Licio Augusto ^{[7
,8
]}

Proenca-Modena, Jose Luiz ^{[3
,5
]}

Mendes Moraes-Vieira, Pedro Manoel ^{[5
,9
]}

Silva Mori, Marcelo Alves ^{[5
,10
]}

Farias, Alessandro Santos ^{[5
,11
]}

Ramirez Vinolo, Marco Aurelio ^{[1
,5
]}

Leal, Raquel Franco ^{[2
,8
]}

机构：

[1] Univ Estadual Campinas, UNICAMP, Dept Genet Microbiol & Immunol, Lab Immunoinflammat,Inst Biol, Campinas, SP, Brazil

[2] Univ Estadual Campinas, UNICAMP, Sch Med Sci,Dept Surg, Inflammatory Bowel Dis Res Lab,Colorectal Surg Un, Campinas, SP, Brazil

[3] Univ Estadual Campinas, UNICAMP, Dept Genet Microbiol & Immunol, Lab Emerging Viruses,Inst Biol, Campinas, SP, Brazil

[4] Univ Estadual Campinas, UNICAMP, Dept Biochem & Tissue Biol, Brazilian Lab Silencing Technol Blast,Inst Biol, Campinas, Brazil

[5] Univ Estadual Campinas, UNICAMP, Expt Med Res Cluster EMRC, Campinas, Brazil

[6] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Lab Neuroprote,UNICAMP, Campinas, SP, Brazil

[7] Univ Estadual Campinas, Sch Med Sci, Lab Cell Signaling, UNICAMP, Campinas, SP, Brazil

[8] Univ Estadual Campinas, UNICAMP, Obes & Comorbid Res Ctr OCRC, Campinas, Brazil

[9] Univ Estadual Campinas, Inst Biol, Dept Genet Microbiol & Immunol, Lab Immunometab,UNICAMP, Campinas, SP, Brazil

[10] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Lab Aging Biol,UNICAMP, Campinas, SP, Brazil

[11] Univ Estadual Campinas, Inst Biol, Dept Genet Microbiol & Immunol, Autoimmune Res Lab,UNICAMP, Campinas, SP, Brazil

来源：

GUT MICROBES | 2021年 / 13卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

SARS-CoV-2; COVID-19; microbiota; short-chain fatty acids; human colonic samples;

D O I：

10.1080/19490976.2021.1874740

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Microbiota-derived molecules called short-chain fatty acids (SCFAs) play a key role in the maintenance of the intestinal barrier and regulation of immune response during infectious conditions. Recent reports indicate that SARS-CoV-2 infection changes microbiota and SCFAs production. However, the relevance of this effect is unknown. In this study, we used human intestinal biopsies and intestinal epithelial cells to investigate the impact of SCFAs in the infection by SARS-CoV-2. SCFAs did not change the entry or replication of SARS-CoV-2 in intestinal cells. These metabolites had no effect on intestinal cells' permeability and presented only minor effects on the production of anti-viral and inflammatory mediators. Together our findings indicate that the changes in microbiota composition of patients with COVID-19 and, particularly, of SCFAs do not interfere with the SARS-CoV-2 infection in the intestine.

引用

页码：1 / 9

页数：9

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