Signal transduction - A cellular rescue team

被引:38
作者
Pomerantz, JL [1 ]
Baltimore, D [1 ]
机构
[1] CALTECH, Div Biol, Pasadena, CA 91125 USA
关键词
D O I
10.1038/35017673
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A protein called glycogen synthase kinase-3β is already known to participate in early embryonic development and cell-fate determination. Now it seems that the protein is also involved in a cell’s decision to live or die.
引用
收藏
页码:26 / 29
页数:4
相关论文
共 16 条
[1]  
Barker N, 2000, ADV CANCER RES, V77, P1
[2]   EMBRYONIC LETHALITY AND LIVER DEGENERATION IN MICE LACKING THE RELA COMPONENT OF NF-KAPPA-B [J].
BEG, AA ;
SHA, WC ;
BRONSON, RT ;
GHOSH, S ;
BALTIMORE, D .
NATURE, 1995, 376 (6536) :167-170
[3]   An essential role for NF-kappa B in preventing TNF-alpha-induced cell death [J].
Beg, AA ;
Baltimore, D .
SCIENCE, 1996, 274 (5288) :782-784
[4]  
Dale TC, 1998, BIOCHEM J, V329, P209
[5]   Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality [J].
Doi, TS ;
Marino, MW ;
Takahashi, T ;
Yoshida, T ;
Sakakura, T ;
Old, LJ ;
Obata, Y .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :2994-2999
[6]   Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation [J].
Hoeflich, KP ;
Luo, J ;
Rubie, EA ;
Tsao, MS ;
Jin, O ;
Woodgett, JR .
NATURE, 2000, 406 (6791) :86-90
[7]   Severe liver degeneration in mice lacking the IκB kinase 2 gene [J].
Li, QT ;
Van Antwerp, D ;
Mercurio, F ;
Lee, KF ;
Verma, IM .
SCIENCE, 1999, 284 (5412) :321-325
[8]   The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis [J].
Li, ZW ;
Chu, WM ;
Hu, YL ;
Delhase, M ;
Deerinck, T ;
Ellisman, M ;
Johnson, R ;
Karin, M .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (11) :1839-1845
[9]   Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappa B activation prevents cell death [J].
Liu, ZG ;
Hsu, HL ;
Goeddel, DV ;
Karin, M .
CELL, 1996, 87 (03) :565-576
[10]  
Rudolph D, 2000, GENE DEV, V14, P854