Hepatitis due to Reactivation of Hepatitis B Virus in Endemic Areas Among Patients With Hepatitis C Treated With Direct-acting Antiviral Agents

被引：157

作者：

Wang, Cheng ^{[1
,2
]}

Ji, Dong ^{[3
,4
]}

Chen, Jing ^{[1
]}

Shao, Qing ^{[3
]}

Li, Bing ^{[3
]}

Liu, Jialiang ^{[3
]}

Wu, Vanessa ^{[1
]}

Wong, April ^{[1
]}

Wang, Yudong ^{[1
]}

Zhang, Xiaoyong ^{[2
]}

Lu, Lei ^{[1
]}

Wong, Chris ^{[5
]}

Tsang, Stella ^{[5
]}

Zhang, Zheng ^{[6
]}

Sun, Jian ^{[2
]}

Hou, Jinlin ^{[2
]}

Chen, Guofeng ^{[3
]}

Lau, George ^{[1
,3
,6
]}

机构：

[1] Humanity & Hlth Med Ctr, Div Gastroenterol & Hepatol, Unit 2101,21-F,9 Queens Rd Cent, Hong Kong, Hong Kong, Peoples R China

[2] Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Viral Hepatitis Res, State Key Lab Organ Failure Res,Dept Infect Dis, Guangzhou, Guangdong, Peoples R China

[3] 302 Hosp, Liver Cirrhosis Diag & Treatment Ctr 2, Beijing, Peoples R China

[4] 302 Hosp, Liver Failure Treatment & Res Ctr, Beijing, Peoples R China

[5] Hong Kong Mol Pathol Diagnost Ctr, Hong Kong, Hong Kong, Peoples R China

[6] 302 Hosp, Inst Translat Hepatol, Beijing, Peoples R China

来源：

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2017年 / 15卷 / 01期

关键词：

Therapy; Risk Factor; Coinfection; Prognostic Factor; INFECTION; CHEMOTHERAPY; SUPERINFECTION; COINFECTION;

D O I：

10.1016/j.cgh.2016.06.023

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis due to reactivation of hepatitis B virus (HBV) has been reported in patients treated with direct-acting antiviral (DAA) agents for chronic hepatitis C virus infection. We performed an observational study to determine the incidence of and factors associated with hepatitis in 327 patients receiving pan-oral DAA agents for HCV infections in areas endemic for HBV in China. Ten patients were positive for hepatitis B surface antigen (HBsAg), and 124 patients had occult HBV infection. HBV reactivation was determined by measuring HBV DNA and HBsAg status in serial serum samples collected every 2 weeks during DAA treatment and then every 4 weeks after treatment until week 12. In the total study population, 10 patients (3.1%) had hepatitis; 3 cases were associated with HBV reactivation (1 case not in the icteric phase, 1 case in the icteric phase, and 1 case with liver failure) and 7 from other causes. Testing positive for HBsAg before DAA treatment was a strong risk factor for developing hepatitis during treatment (hazard ratio, 15.0; P < .001).

引用

页码：132 / 136

页数：5

共 20 条

[1] Causes of death after diagnosis of hepatitis B or hepatitis C infection: a large community-based linkage study [J].

Amin, Janaki ;

Law, Matthew G. ;

Bartlett, Mark ;

Kaldor, John M. ;

Dore, Gregory J. .

LANCET, 2006, 368 (9539) :938-945

[2] Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir [J].

Collins, Jeffrey M. ;

Raphael, Kara Loren ;

Terry, Charles ;

Cartwright, Emily J. ;

Pillai, Anjana ;

Anania, Frank A. ;

Farley, Monica M. .

CLINICAL INFECTIOUS DISEASES, 2015, 61 (08) :1304-1306

[3] Direct-acting antiviral treatment in adults infected with hepatitis C virus: Reactivation of hepatitis B virus coinfection as a further challenge [J].

De Monte, Anne ;

Courjon, Johan ;

Anty, Rodolphe ;

Cua, Eric ;

Naqvi, Alissa ;

Mondain, Veronique ;

Cottalorda, Jacqueline ;

Ollier, Laurence ;

Giordanengo, Valerie .

JOURNAL OF CLINICAL VIROLOGY, 2016, 78 :27-30

[4] Fulminant hepatitis B reactivation leading to liver transplantation in a patient with chronic hepatitis C treated with simeprevir and sofosbuvir: A case report [J].

Ende A.R. ;

Kim N.H. ;

Yeh M.M. ;

Harper J. ;

Landis C.S. .

Journal of Medical Case Reports, 9 (1)

[5]

Fukuda R, 1999, J MED VIROL, V58, P201, DOI 10.1002/(SICI)1096-9071(199907)58:3<201::AID-JMV3>3.0.CO

[6]

2-2

[7] Regulation of hepatic innate immunity by hepatitis C virus [J].

Horner, Stacy M. ;

Gale, Michael, Jr. .

NATURE MEDICINE, 2013, 19 (07) :879-888

[8]

Hui CK, 2006, GASTROENTEROLOGY, V131, P59, DOI 10.1053/j.gastro.2006.04.015

[9] Hepatitis B reactivation after chemotherapy: two decades of clinical research [J].

Lau, George K. K. .

HEPATOLOGY INTERNATIONAL, 2008, 2 (02) :152-162

[10] DISPLACEMENT OF HEPATIITIS-B VIRUS HEPATITIS-C VIRUS AS THE CAUSE OF CONTINUING CHRONIC HEPATITIS [J].

LIAW, YF ;

TSAI, SL ;

CHANG, JJ ;

SHEEN, IS ;

CHIEN, RN ;

LIN, DY ;

CHU, CM .

GASTROENTEROLOGY, 1994, 106 (04) :1048-1053

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