HIV-resistant dual CD28/4-1BB costimulated CAR T cells mitigate HIV pathogenesis in humanized mice

被引：0
|
作者：
Claiborne, D. [1 ]
Maldini, C. [2 ]
Okawa, K. [3 ]
Chen, T. [1 ]
Dopkin, D. [2 ]
Shan, X. [2 ]
Power, K. [1 ]
Trifonova, R. [1 ]
Krupp, K. [1 ]
Phelps, M. [1 ]
Vrbanac, V. [1 ]
Tanno, S. [1 ]
Bateson, T. [1 ]
Leslie, G. [2 ]
Hoxie, J. [2 ]
机构：
[1] Massachusetts Gen Hosp, Ragon Inst MGH MIT & Harvard, Boston, MA 02114 USA
[2] Univ Penn, Philadelphia, PA 19104 USA
[3] Ragon Inst MGH MIT & Harvard, Boston, MA USA
来源：
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY | 2021年 / 24卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
OA20.02
引用
收藏
页数：1
相关论文
共 50 条
  • [41] CD28 Co-Stimulus Achieves Superior CAR T Cell Effector Function against Solid Tumors Than 4-1BB Co-Stimulus
    Textor, Ana
    Grunewald, Laura
    Anders, Kathleen
    Klaus, Anika
    Schwiebert, Silke
    Winkler, Annika
    Stecklum, Maria
    Rolff, Jana
    Henssen, Anton G.
    Hoepken, Uta E.
    Eggert, Angelika
    Schulte, Johannes H.
    Jensen, Michael C.
    Blankenstein, Thomas
    Kuenkele, Annette
    CANCERS, 2021, 13 (05) : 1 - 17
  • [42] PSMA-Specific CAR-Engineered T Cells for Prostate Cancer: CD28 Outperforms Combined CD28-4-1BB "Super-Stimulation"
    Zuccolotto, Gaia
    Penna, Alessandro
    Fracasso, Giulio
    Carpanese, Debora
    Montagner, Isabella Monia
    Dalla Santa, Silvia
    Rosato, Antonio
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [43] Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway
    Ott, M
    Emiliani, S
    VanLint, C
    Herbein, G
    Lovett, J
    Chirmule, N
    McCloskey, T
    Pahwa, S
    Verdin, E
    SCIENCE, 1997, 275 (5305) : 1481 - 1485
  • [44] 4-1BB and CD28 Signaling Plays a Synergistic Role in Redirecting Umbilical Cord Blood T Cells Against B-Cell Malignancies
    Tammana, Syam
    Huang, Xin
    Milone, Michael
    Ma, Linan
    Levine, Bruce L.
    June, Carl H.
    Wagner, John E.
    Zhou, Xianzheng
    MOLECULAR THERAPY, 2009, 17 : S214 - S214
  • [45] 4-1BB and CD28 Signaling Plays a Synergistic Role in Redirecting Umbilical Cord Blood T Cells Against B-Cell Malignancies
    Tammana, Syam
    Huang, Xin
    Wong, Marianna
    Milone, Michael C.
    Ma, Linan
    Levine, Bruce L.
    June, Carl H.
    Wagner, John E.
    Blazar, Bruce R.
    Zhou, Xianzheng
    HUMAN GENE THERAPY, 2010, 21 (01) : 75 - 86
  • [46] CD8+NKT cells, low in cord blood, preferentially require 4-1BB rather than CD28 for costimulation.
    Kim, YJ
    Broxmeyer, HE
    BLOOD, 2000, 96 (11) : 240A - 240A
  • [47] Cooperation between 4-1BB and ICOS in the immune response to influenza virus revealed by studies of CD28/ICOS-deficient mice
    Vidric, M
    Suh, WK
    Dianzani, U
    Mak, TW
    Watts, TH
    JOURNAL OF IMMUNOLOGY, 2005, 175 (11): : 7288 - 7296
  • [48] Engineering HIV-Resistant Human CD4+T Cells with CXCR4-Specific Zinc-Finger Nucleases
    Wilen, Craig B.
    Wang, Jianbin
    Tilton, John C.
    Miller, Jeffrey C.
    Kim, Kenneth A.
    Rebar, Edward J.
    Sherrill-Mix, Scott A.
    Patro, Sean C.
    Secreto, Anthony J.
    Jordan, Andrea P. O.
    Lee, Gary
    Kahn, Joshua
    Aye, Pyone P.
    Bunnell, Bruce A.
    Lackner, Andrew A.
    Hoxie, James A.
    Danet-Desnoyers, Gwenn A.
    Bushman, Frederic D.
    Riley, James L.
    Gregory, Philip D.
    June, Carl H.
    Holmes, Michael C.
    Doms, Robert W.
    PLOS PATHOGENS, 2011, 7 (04)
  • [49] The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells
    Emily N. Pawlak
    Brennan S. Dirk
    Rajesh Abraham Jacob
    Aaron L. Johnson
    Jimmy D. Dikeakos
    Retrovirology, 15
  • [50] Role of 4-1BB (CD137) in the functional activation of cord blood CD28-CD8+ T cells
    Kim, YJ
    Brutkiewicz, RR
    Broxmeyer, HE
    BLOOD, 2002, 100 (09) : 3253 - 3260
12345