Asymmetric synthesis of (R)- and (S)-2-pyrrolidinemethanesulfonic acid

被引：37

作者：

Braghiroli, D ^{[1
]}

Avallone, R ^{[1
]}

DiBella, M ^{[1
]}

机构：

[1] UNIV MODENA,DIPARTIMENTO SCI FARMACEUT,I-41100 MODENA,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 13期

关键词：

D O I：

10.1016/S0957-4166(97)00196-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(R)- and (S)-2-Pyrrolidinemethanesulfonic acid, 3a and 3b, were synthesized from the corresponding N-Boc-2-(hydroxymethyl)-1-pyrrolidine, 6a and 6b. This asymmetric synthesis proceeds in mild conditions, with good overall yields and high enantiomeric purities (>99% ee). (C) 1997 Elsevier Science Ltd.

引用

页码：2209 / 2213

页数：5

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