New benzyl-aporphine alkaloids from Thalictrum cultratum

被引：6

作者：

Kang, Wenjia ^{[1
,2
]}

Li, Jianyong ^{[1
,2
]}

Li, Dahong ^{[1
,2
]}

Li, Zhanlin ^{[1
,2
]}

Chen, Shengshuang ^{[1
,2
]}

Hua, Huiming ^{[1
,2
]}

Bai, Jiao ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 21期

关键词：

Thalictrum cultratum; alkaloid; benzyl-aporphine dimmer; cytotoxicity; BISBENZYLISOQUINOLINE ALKALOIDS; ROOTS;

D O I：

10.1080/14786419.2018.1523160

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new rare benzyl-aporphine alkaloids, thaliculine (1) and 6a,7-dehydrothaliculine (2), were isolated from the roots of Thalictrum cultratum Wall. Their structures were determined based on spectroscopic analysis including 1D, 2D NMR, and HR-ESI-MS. The stereochemistry of 1 was assigned by ECD spectroscopy. Compound 1 exhibited weak cytotoxicity against HL-60 cell line with IC50 value of 31.40 mu M.

引用

页码：3176 / 3179

页数：4

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