The DNA replication regulator MCM6: An emerging cancer biomarker and target

被引：48
作者：
Zeng, Tian [1 ]
Guan, Yang [2 ]
Li, Yu-kun [1 ]
Wu, Qing [3 ]
Tang, Xiao-jun [4 ]
Zeng, Xin [5 ]
Ling, Hui [1 ]
Zou, Juan [1 ]
机构：
[1] Univ South China, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China
[2] Jiangxi Univ Tradit Chinese Med, Nanchang 330000, Jiangxi, Peoples R China
[3] Univ South China, Affiliated Nanhua Hosp, Dept Digest Med, Hengyang 421002, Peoples R China
[4] Univ South China, Affiliated Hosp 2, Dept Spinal Surg, Hengyang 421001, Hunan, Peoples R China
[5] Chongqing Three Gorges Med Coll, Dept Histol & Embryol, Chongqing 404000, Peoples R China
来源：
CLINICA CHIMICA ACTA | 2021年 / 517卷
关键词：
MCM6; DNA replication regulator; Proliferation; Invasion; Biomarker; MINICHROMOSOME MAINTENANCE PROTEINS; SQUAMOUS-CELL CARCINOMA; COMPLEX COMPONENT 6; S-PHASE; BREAST-CANCER; RE-REPLICATION; HUMAN GENE; EXPRESSION; CYCLE; PROLIFERATION;
D O I：
10.1016/j.cca.2021.02.005
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
MCM6 is a significant DNA replication regulator that plays a crucial role in sustaining the cell cycle. In many cancer cells, MCM6 expression is enhanced. For example, persistently increased expression of MCM6 promotes the formation, development and progression of hepatocellular carcinoma (HCC). Up- and down-regulation studies have indicated that MCM6 regulates cell cycle, proliferation, metastasis, immune response and the maintenance of the DNA replication system. MCM6 can also regulate downstream signaling such as MEK/ERK thus promoting carcinogenesis. Accordingly, MCM6 may represent a sensitive and specific biomarker to predict adverse progression and poor outcome. Furthermore, inhibition of MCM6 may be an effective cancer treatment. The present review summarizes the latest results on the inactivating and activating functions of MCM6, underlining its function in carcinogenesis. Further studies of the carcinogenic functions of MCM6 may provide novel insight into cancer biology and shed light on new approaches for cancer diagnosis and treatment.
引用
收藏
页码：92 / 98
页数：7
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