Antimicrobial activity of tigecycline and cefoperazone/sulbactam tested against 18,386 Gram-negative organisms from Europe and the Asia-Pacific region (2013-2014)

A total of 18,386 organisms, including 13,224 Enterobacteriaceae, 3536 Pseudomonas aeruginosa, 1254 Acinetobacter spp., and 372 Stenotrophomonas maltophilia were collected from Western Europe (WEU; n = 10,021), Eastern Europe (EEU; n = 4957), and the Asia-Pacific region (APAC; n = 3408 11052 from China]) in 2013-2014 as part of the SENTRY Antimicrobial Surveillance Program and tested by a reference broth microdilution method for susceptibility against tigecycline, cefoperazone/sulbactam, and comparator agents. Overall, 95.3% of Enterobacteriaceae were susceptible (<= 1 mu g/mL; EUCAST) to tigecycline (MIC50/90, 0.12/ 1 mu g/mL) with regional EUCAST susceptibility rates of 94.8-97.8% (98.9-99.6% inhibited at <= 2 mu g/mL[US FDA]). Among Acinetobacter spp., 66.1% (EEU) and 79.5% (WEU) were inhibited at <= 1 mu g/mL of tigecycline (94.9% and 97.3% inhibited at <= 2 mu g/mL; pan-European MIC50/90. 1/2 mu g/mL). For S. maltophilia, 65.4% (China) to 88.9% (EEU) of the isolates were inhibited at <= 1 mu g/mL of tigecycline. Cefoperazone/sulbactam inhibited 94.6/83.5/ 91.5% of Enterobacteriaceae at <= 16 mu g/mL in WEU/EEU/APAC, respectively. (C) 2017 Elsevier Inc. All rights reserved.