Lupus anticoagulant hypoprothrombinemia syndrome associated with severe thrombocytopenia in a child

被引：7

作者：

Foord, Aimee ^{[1
]}

Baca, Nicole ^{[2
]}

Buchbinder, David ^{[3
]}

Mahajerin, Arash ^{[4
]}

机构：

[1] Seattle Childrens Hosp, Div Pediat, Hematol Oncol Hospitalist Serv, 4800 Sand Point Way NE, Seattle, WA 98105 USA

[2] CHOC Childrens Hosp, Div Hematol Oncol, Orange, CA USA

[3] CHOC Childrens Hosp, Div Hematol Bone Marrow Transplant, Orange, CA USA

[4] CHOC Childrens Hosp, Div Hematol, Orange, CA USA

来源：

PEDIATRIC BLOOD & CANCER | 2017年 / 64卷 / 06期

关键词：

hypoprothrombinemia; lupus coagulation inhibitor; pediatrics; thrombocytopenia; PROTHROMBIN; HEMORRHAGE;

D O I：

10.1002/pbc.26357

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) comprises lupus anticoagulant, acquired hypoprothrombinemia, and often mild thrombocytopenia or normal platelets. It is usually associated with autoimmunity or postviral illness. We describe a case of a 10-year-old boy with oral bleeding and severe thrombocytopenia initially suggestive of immune thrombocytopenia. Secondary to bleeding, evaluation demonstrated prolonged coagulation tests and subsequently revealed the presence of lupus anticoagulant and hypoprothrombinemia, along with marked autoimmunity, suggestive of LAHPS. He was treated with intravenous immunoglobulin and hydroxychloroquine. This case report and discussion highlight the diagnostic and therapeutic challenges associated with LAHPS and coincident severe thrombocytopenia.

引用

页数：4