Use of Transdermal Melatonin Delivery to Improve Sleep Maintenance During Daytime

被引：39

作者：

Aeschbach, D. ^{[1
,2
]}

Lockyer, B. J. ^{[1
]}

Dijk, D-J ^{[3
]}

Lockley, S. W. ^{[1
,2
]}

Nuwayser, E. S. ^{[4
]}

Nichols, L. D. ^{[4
]}

Czeisler, C. A. ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Div Sleep Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Div Sleep Med, Boston, MA USA

[3] Univ Surrey, Surrey Sleep Res Ctr, Guildford GU2 5XH, Surrey, England

[4] Biotek, Wellesley, MA USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2009年 / 86卷 / 04期

关键词：

CONTROLLED-RELEASE; FREQUENCY ACTIVITY; EXTENDED SLEEP; MEN; MODULATION; PHASE; YOUNG; TIME;

D O I：

10.1038/clpt.2009.109

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oral melatonin (MEL) can improve daytime sleep, but the hormone's short elimination half-life limits its use as a hypnotic in shift workers and individuals with jet lag or other sleep problems. Here we show, in healthy subjects, that transdermal delivery of MEL during the daytime can elevate plasma MEL and reduce waking after sleep onset, by promoting sleep in the latter part of an 8-h sleep opportunity. Transdermal MEL may have advantages over fast-release oral MEL in improving sleep maintenance during adverse circadian phases.

引用

页码：378 / 382

页数：5

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