Tamiflu: The supply problem

被引：131
作者：
Farina, Vittorio
Brown, Jack D.
机构：
[1] Boehringer Ingelheim Pharmaceut Inc, Dept Chem Dev, Ridgefield, CT 06877 USA
[2] Boehringer Ingelheim Chem, Dept Dev, Petersburg, VA 23805 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 44期
关键词：
antiviral agents; inhibitors; quinic acid; shikimic acid; synthetic methods;
D O I：
10.1002/anie.200602623
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Taming of the flu: Shikimic and quinic acids are the established starting materials for Tamiflu, a viral neuraminidase inhibitor that is considered by many as the first-line treatment against a possible H5N1 (bird flu) pandemic. Several syntheses have been described recently that circumvent the use of these natural products. These, or related approaches, may provide an alternative practical approach to this important drug. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：7330 / 7334
页数：5
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