Iron(II)-Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation

被引：65

作者：

Roy, Satyajit ^{[1
]}

Khatua, Hillol ^{[1
]}

Das, Sandip Kumar ^{[1
]}

Chattopadhyay, Buddhadeb ^{[1
]}

机构：

[1] Ctr Biomed Res CBMR, Div Mol Synth & Drug Discovery, SGPGIMS Campus,Raebareli Rd, Lucknow 226014, Uttar Pradesh, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 33期

关键词：

annulations; iron; nitrogen heterocycles; nitrenes; radicals; C-H AMINATION; SUBSTITUTED DIAZO REAGENTS; ASYMMETRIC RADICAL CYCLOPROPANATION; C(SP(3))-H BONDS; CATALYSIS; AZIDES; ALKENES; AZIRIDINATION; CONSTRUCTION; TRANSANNULATION;

D O I：

10.1002/anie.201904702

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A unique concept for the intermolecular denitrogenative annulation of 1,2,3,4-tetrazoles and alkynes was discovered by using a catalytic amount of Fe(TPP)Cl and Zn dust. The reaction precludes the traditional, more favored click reaction between an organic azide and alkynes, and instead proceeds by an unprecedented metalloradical activation. The method is anticipated to advance access to the construction of important basic nitrogen heterocycles, which will in turn enable discoveries of new drug candidates.

引用

页码：11439 / 11443

页数：5

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