Advances in the Treatment of Cholinergic Anti-Inflammatory Pathways in Gastrointestinal Diseases by Electrical Stimulation of Vagus Nerve

被引：22
作者：
Lei, Wei [1 ,2 ]
Duan, Zhijun [1 ,2 ]
机构：
[1] Dalian Med Univ, Dept Gastroenterol 2, Affiliated Hosp 1, 222 Zhongshan Rd, Dalian 0086116011, Liaoning, Peoples R China
[2] Dalian Med Univ, Lab Integrated Chinese & Western Med, Affiliated Hosp 1, Dalian, Peoples R China
来源：
DIGESTION | 2021年 / 102卷 / 02期
关键词：
Cholinergic anti-inflammatory pathway; Vagus nerve stimulation; α 7 nicotinic acetylcholine receptor; Gastrointestinal tract; NICOTINIC ACETYLCHOLINE-RECEPTOR; SYSTEMIC INFLAMMATORY RESPONSE; TREATMENT-RESISTANT DEPRESSION; VAGAL INNERVATION; RAT MODEL; POSTOPERATIVE ILEUS; BARRIER DYSFUNCTION; CYTOKINE PRODUCTION; MESSENGER-RNA; IMMUNE-SYSTEM;
D O I：
10.1159/000504474
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background: The cholinergic anti-inflammatory pathway (CAIP) has been proposed as a key mechanism by which the brain, through the vagus nerve (VN), modulates the immune system in the body. Recent studies of VN stimulation (VNS) in vivo systems have shown that it plays an anti-inflammatory role through CAIP. Inflammatory diseases in the gastrointestinal tract are frequent and difficult to treat. Summary: The mechanism of the anti-inflammatory effect of VNS through CAIP is not fully known. The current review covers anatomy, molecular mechanisms, and the application in gastrointestinal diseases of the vagal CAIP. Key Messages: CAIP bridges immune and nervous systems and plays pleiotropic roles in modulating inflammation in animal models by targeting different immune, proinflammatory, epithelial and endothelial cells, and signaling pathways. Numerous animal studies have shown beneficial effects of stimulation of this pathway in models of inflammatory diseases, either through (electrical) stimulation of the VN or pharmacological approaches. In this review, we focus on the anti-inflammatory benefits of VNS as a means of providing new insights into treating inflammation-related gastrointestinal diseases, as exemplified by those described herein.
引用
收藏
页码：128 / 138
页数：11
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