Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumannii

被引：148
作者：
Vila, J
Ruiz, J
Goni, P
deAnta, TJ
机构：
[1] Department of Microbiology, School of Medicine, University of Barcelona, 08036 Barcelona
[2] Laboratorio de Microbiologia, Hospital Clínic, Universitat de Barcelona, 08036 Barcelona, Villarroel
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1997年 / 39卷 / 06期
关键词：
D O I：
10.1093/jac/39.6.757
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Mutations in the parC gene, which encodes a subunit of topoisomerase IV, were determined in 21 epidemiologically unrelated clinical isolates of Acinetobacter baumannii. Our studies highlight the conserved sequences in the quinolone-resistance-determining region of the parC gene from A. baumannii and other bacteria. Nine of ten isolates with MICs of ciprofloxacin of greater than or equal to 32 mg/L showed a change of Ser80 to Leu and one showed a change of Glu84 to Lys. These results suggest that ParC from A. baumannii is a secondary target for quinolones and that mutations at residues Ser80 and Glu84, when combined with mutations at Ser83 of GyrA, may render A, baumannii highly resistant to quinolones.
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页码：757 / 762
页数：6
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