Common disorders are quantitative traits

被引：511
作者：
Plomin, Robert [1 ]
Haworth, Claire M. A. [1 ]
Davis, Oliver S. P. [1 ]
机构：
[1] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
来源：
NATURE REVIEWS GENETICS | 2009年 / 10卷 / 12期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
GENOME-WIDE ASSOCIATION; GENETIC RISK; SUSCEPTIBILITY LOCI; BREAST-CANCER; CROHN-DISEASE; PREDICTION; VARIANT; PATHOGENESIS; CHALLENGES; PHENOTYPE;
D O I：
10.1038/nrg2670
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
After drifting apart for 100 years, the two worlds of genetics quantitative genetics and molecular genetics - are finally coming together in genome-wide association (GWA) research, which shows that the heritability of complex traits and common disorders is due to multiple genes of small effect size. We highlight a polygenic framework, supported by recent GWA research, in which qualitative disorders can be interpreted simply as being the extremes of quantitative dimensions. Research that focuses on quantitative traits including the low and high ends of normal distributions - could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits.
引用
收藏
页码：872 / 878
页数：7
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