PEGylated polymers for medicine: from conjugation to self-assembled systems

被引：201

作者：

Joralemon, Maisie J. ^{[1
]}

McRae, Samantha ^{[1
]}

Emrick, Todd ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 09期

关键词：

CROSS-LINKED NANOPARTICLES; BLOCK-COPOLYMER MICELLES; DRUG-DELIVERY SYSTEMS; OPENING METATHESIS POLYMERIZATION; AMPHIPHILIC GRAFT-COPOLYMERS; IN-VIVO; POLYETHYLENE-GLYCOL; GENE DELIVERY; BIODEGRADABLE POLYESTERS; ALIPHATIC POLYESTERS;

D O I：

10.1039/b920570p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthetic polymers have transformed society in many areas of science and technology, including recent breakthroughs in medicine. Synthetic polymers now offer unique and versatile platforms for drug delivery, as they can be "io-tailored'' for applications as implants, medical devices, and injectable polymer-drug conjugates. However, while several currently used therapeutic proteins and small molecule drugs have benefited from synthetic polymers, the full potential of polymer-based drug delivery platforms has not yet been realized. This review examines both general advantages and specific cases of synthetic polymers in drug delivery, focusing on PEGylation in the context of polymer architecture, self-assembly, and conjugation techniques that show considerable effectiveness and/or potential in therapeutics.

引用

页码：1377 / 1393

页数：17

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