Synthesis of a dinucleating ligand with addressed ion binding sites

被引：11
|
作者：
dosSantos, O [1 ]
Lajmi, AR [1 ]
Canary, JW [1 ]
机构：
[1] NYU,DEPT CHEM,NEW YORK,NY 10003
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 25期
关键词：
D O I：
10.1016/S0040-4039(97)00937-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ligand was synthesized that contains two binding sites, differentiated on the basis of size and donor atom. The binding profile for a series of amino acid guests suggest that the two binding sites are 6.5 Angstrom apart. Kinetic studies of hydrolysis of a model phosphodiester substrate by heterodinuclear complexes of the ligand suggest that one metal ion delivers a hydroxide nucleophile and the other increases substrate binding although not in the ideal geometry. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：4383 / 4386
页数：4
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