The influence of temperament on symptoms and functional outcome in people with psychosis in the Northern Finland 1966 Birth Cohort

Objective: To describe symptom expression and functional outcome in psychotic disorders in relation with temperament traits assessed with the Temperament and Character Inventory (TCI) in a population-based sample. Method: As part of the 31-year follow-up survey of the Northern Finland 1966 Birth Cohort, TO temperament items were filled in by 4349 members of the cohort. In individuals with psychotic disorders, also positive and negative symptoms and outcome variables were assessed in a 35-year follow-up. Information of TCI and outcomes were available for altogether 41 individuals with psychosis. Result: Reward dependence (RD) (rho = -0.45) and Persistence (P) (rho = -0.52) were significantly correlated with Positive and Negative Syndrome Scale (PANSS) negative symptoms. Higher P scores predicted higher social and occupational functioning (as measured by Social and Occupational Functioning Assessment Scale [SOFAS]), and higher Harm avoidance (HA) predicted a higher likelihood of being on a disability pension. Conclusion: Results indicate that understanding of personality dimensions support better understanding of outcome and symptom expressions in psychotic disorders. (C) 2009 Published by Elsevier Masson SAS.