An efficient and practical N-methylation of amino acid derivatives

被引：48
|
作者：
Prashad, M [1 ]
Har, D [1 ]
Hu, B [1 ]
Kim, HY [1 ]
Repic, O [1 ]
Blacklock, TJ [1 ]
机构：
[1] Novartis Inst Biomed Res, E Hanover, NJ 07936 USA
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 02期
关键词：
D O I：
10.1021/ol0268440
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and practical N-methylation of amino acid derivatives with dimethyl sulfate in the presence of sodium hydride and a catalytic amount of water is described. Reaction of water with sodium hydride generated highly reactive dry sodium hydroxide, which led to much faster reaction rates than powdered sodium hydroxide itself.
引用
收藏
页码：125 / 128
页数：4
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