Mathematical analysis for an age-structured SIRS epidemic model

被引:20
作者
Okuwa, Kento [1 ]
Inaba, Hisashi [1 ]
Kuniya, Toshikazu [2 ]
机构
[1] Univ Tokyo, Grad Sch Math Sci, Meguro Ku, 3-8-1 Komaba, Tokyo 1538914, Japan
[2] Kobe Univ, Grad Sch Syst Informat, Nada Ku, 1-1 Rokkodai Cho, Kobe, Hyogo 6578501, Japan
基金
日本学术振兴会;
关键词
SIRS epidemic; basic reproduction number; age structure; forward bifurcation; persistence; compact attractor; ROYAL SOCIETY; IMMUNITY; REINFECTION; STABILITY; ENDEMICITY; INFECTION; THRESHOLD; EXPOSURE; KERMACK;
D O I
10.3934/mbe.2019304
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this paper, we investigate an SIRS epidemic model with chronological age structure in a demographic steady state. Although the age-structured SIRS model is a simple extension of the well-known age-structured SIR epidemic model, we have to develop new technique to deal with problems due to the reversion of susceptibility for recovered individuals. First we give a standard proof for the well-posedness of the normalized age-structured SIRS model. Next we examine existence of endemic steady states by fixed point arguments and bifurcation method, where we introduce the next generation operator and the basic reproduction number R-0 to formulate endemic threshold results. Thirdly we investigate stability of steady states by the bifurcation calculation and the comparison method, and we show existence of a compact attractor and discuss the global behavior based on the population persistence theory. Finally we give some numerical examples and discuss the effect of mass-vaccination on R-0 and the critical coverage of immunization based on the reinfection threshold.
引用
收藏
页码:6071 / 6102
页数:32
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